Research progress on the relationship between gut microbiota and thyroid nodules
10.3760/cma.j.cn115807-20241209-00379
- VernacularTitle:肠道菌群与甲状腺结节相关性的研究进展
- Author:
Xiang CHEN
1
;
Lingling XU
;
Jiaxin CHEN
;
Yingchun ZHANG
;
Jingping CHENG
Author Information
1. 武汉科技大学医学部医学院,武汉 430065
- Publication Type:Journal Article
- Keywords:
Gut microbiota;
Thyroid nodules;
Gut-thyroid axis;
Dysbiosis
- From:
Chinese Journal of Endocrine Surgery
2025;19(3):449-452
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid nodules are a common endocrine disorder with complex pathogenesis that remains incompletely understood. In recent years, studies have revealed that the gut microbiota may play a critical role in the occurrence and progression of thyroid nodules. This review systematically summarizes the current research progress on the association between gut microbiota and thyroid nodules, with a particular focus on potential mechanisms through which gut dysbiosis influences nodule formation via immune regulation, metabolic pathways, and gut barrier function. Evidence suggests that reduced gut microbial diversity, decreased abundance of specific beneficial bacteria, and an increased proportion of pro-inflammatory bacteria may contribute to a pro-inflammatory environment and metabolic disturbances associated with thyroid nodules. Furthermore, this review explores the potential of interventions such as probiotics, prebiotics, dietary modifications, and fecal microbiota transplantation in modulating gut microbiota and improving thyroid nodule outcomes. Although direct clinical evidence is currently lacking, the regulation of gut microbiota has emerged as a promising direction for the diagnosis and treatment of thyroid nodules, demonstrating significant clinical potential. Future efforts should focus on advancing basic and clinical research strategies to facilitate the translational application of findings in this field.
