How close is fecal microbiota transplantation to moving to precision medicine?
10.3760/cma.j.cn441530-20241220-00415
- VernacularTitle:肠菌移植：如何加速跨入精准时代
- Author:
Xinjun WANG
1
;
Di ZHAO
;
Yunhao QIN
;
Luntian YU
;
Zhan CAO
;
Wenhao LIU
;
Bo YANG
;
Ning LI
;
Qiyi CHEN
;
Huanlong QIN
Author Information
1. 苏州市立医院肠道微生态实验室 南京医科大学附属苏州医院，苏州 215000
- Publication Type:Journal Article
- Keywords:
Fecal microbiota transplantation;
Gastrointestinal diseases;
Colonization antagonism;
Clinical research;
Functional microbiota
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(3):254-260
- CountryChina
- Language:Chinese
-
Abstract:
Fecal microbiota transplantation (FMT) has the potential to rebuild the intestinal microbiome of patients, which can influence the disease course, alleviate symptoms, or even cure the disease. It is seen as a promising breakthrough for treating major chronic diseases that are difficult to manage. Currently, FMT therapy has been clinically studied for over 80 diseases and has led to significant breakthroughs. However, there are still four main challenges: (1) identifying the effective characteristics of donor microbiota and ensuring precise matching between donors and recipients; (2) understanding the pathways and molecular mechanisms by which key FMT bacteria and metabolites improve disease outcomes; (3) studying strain interactions and colonization mechanisms to restore intestinal microbiota balance; and (4) refining the precision of microbiome and functional microbiota transplantation. To address these clinical challenges, this article reviews the latest research both domestically and internationally, outlines the response patterns of FMT therapy, examines the reasons behind FMT failure, and explores future directions for the development of FMT. The aim is to accelerate the scientific and precise advancement of FMT technology in China.
