Phages in human health and gut microbiota transplantation therapy
10.3760/cma.j.cn441530-20241130-00387
- VernacularTitle:肠道噬菌体在人体健康和肠道微生态移植治疗中的作用
- Author:
Yufeng JIN
1
;
Weijie WEN
1
;
Tao ZUO
1
Author Information
1. 中山大学附属第六医院 中山大学胃肠病学研究所 人体微生态与老年慢性疾病教育部重点实验室，广州 510655
- Publication Type:Journal Article
- Keywords:
Gut microbiome;
Phage, gut;
Immune;
Host-microbe;
Phage-bacteria interaction
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(3):261-265
- CountryChina
- Language:Chinese
-
Abstract:
Phages, prokaryotic viruses widely present in the human, are a crucial component of the gut microbiome. They play a significant role in human health and the development of diseases. Emerging evidence indicates that phages can interact with bacteria to affect their abundance, metabolism, and antibiotic resistance, thereby influencing the balance of the gut microbiota. In addition, phages also contribute to the gut immune response, and can become dysregulated in a range of immune-related diseases. Gut phages also carry important roles in fecal microbiota transplantation (FMT) for disease treatment. Phages can target specific bacterial members and communities, thereby reduce the risk of bacterial infections or the presence of bacteria, and maintain the stability of the gut microbiome. However, gut phageome research is still in its infancy and additional basic and clinical researches are required to evaluate its species composition, mechanisms of pathogenicity or protection, as well as its efficacy and safety.
