A review of the research progress on tumor-associated macrophages
- VernacularTitle:肿瘤相关巨噬细胞的研究进展
- Author:
Chengfei HAO
1
;
Guoshan CHEN
;
Xibo ZHANG
;
Feng QI
Author Information
- Publication Type:Journal Article
- Keywords: tumor-associated macrophages; tumor microenvironment; myeloid cells; RNA-Seq; cell communication
- From: Tianjin Medical Journal 2025;53(1):108-112
- CountryChina
- Language:Chinese
- Abstract: In the tumor microenvironment,tumor-associated macrophages construct complex interaction networks through highly plasticity,promoting the dynamic evolution of the cancer ecosystem.With the innovation of single-cell sequencing technology,the heterogeneity,functional diversity,and interaction mechanisms of tumor-associated macrophages with tumor microenvironment have been revealed.This suggests that tumor-associated macrophages may become a new target for tumor targeted therapy,driving the development of precision anti-cancer strategies.This review summarizes the relevant research progress,explores the interaction mechanisms,describes the classification and clinical therapeutic potential,aiming to provide new perspectives and guidance for tumor research and clinical practice.
