Value of lymph node ratio combined with AFP,CA199 and CA724 in prognostic evaluation of patients undergoing surgical treatment for cervical cancer
10.3760/cma.j.cn115807-20250106-00009
- VernacularTitle:淋巴结比率联合AFP、CA199、CA724对宫颈癌手术患者的预后评估价值
- Author:
Huijuan CHEN
1
;
Baomei SHI
1
;
Li XING
1
Author Information
1. 义乌市中心医院妇科，义乌 322000
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Lymph node ratio;
Alpha-fetoprotein;
Carbohydrate antigen 199;
Carbohydrate antigen 724
- From:
Chinese Journal of Endocrine Surgery
2025;19(3):439-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prognostic value of lymph node ratio (LNR) combined with alpha-fetoprotein (AFP), carbohydrate antigen 199 (CA199) and carbohydrate antigen 724 (CA724) in patients undergoing surgical treatment for cervical cancer.Methods:A total of 118 patients with cervical cancer were treated in Yiwu Central Hospital from Jan.2018 to Aug. 2021. Patients with recurrence, metastasis and death during follow-up were included in the poor prognosis group, and vice versa in the good prognosis group. Clinical data, laboratory indicators and LNR, AFP, CA199 and CA724 levels of the subjects were collected. Lasso-Logistic regression analysis was used to screen independent risk factors affecting postoperative poor prognosis of the study subjects, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of LNR combined with AFP, CA199 and CA724 in evaluating postoperative poor prognosis of patients.Results:During the follow-up period, 15 out of 118 patients were lost to follow-up (12.71%, 15/118). Among the remaining 103 patients, 28 patients died, 12 patients had metastasis, and 7 patients had relapse, and the prognosis was 45.63% (47/103). Compared with the good prognosis group, the poor prognosis group had higher clinical stage (stage III), tumor size (> 4.0 cm), differentiation degree (low differentiation), proportion of lymph node metastasis and LNR, AFP, CA199, CA724 levels ( P<0.05). Clinical stage (stage III), differentiation degree (low differentiation), LNR, AFP, CA199, CA724 were independent risk factors for poor prognosis of patients with cervical cancer after surgery ( P<0.05). ROC curve results showed that the area under ROC curve (AUC), 95% CI and specificity of LNR combined with AFP, CA199 and CA724 in evaluating postoperative poor prognosis of cervical cancer patients were 0.904, 0.840-0.969 and 94.60%, respectively, higher than the prediction value of the above indexes alone ( P<0.001) . Conclusion:Abnormal levels of LNR, AFP, CA199 and CA724 are independent risk factors for postoperative poor prognosis in patients with cervical cancer, and the combined detection of these indicators has a higher value in predicting postoperative poor prognosis in patients with cervical cancer.
