Study on the Regularity of Essential Oils from Traditional Chinese Medicine with Hot Property in Enhancing Skin Permeabil-ity of Different Components
10.14148/j.issn.1672-0482.2025.0058
- VernacularTitle:热性中药挥发油透皮促渗不同成分的规律性研究
- Author:
Zhichao SONG
1
;
Senlan HUANG
;
Xixi ZHU
;
Shanshan LU
;
Wenjun LIU
;
Yeqing QU
;
Jun CHEN
Author Information
1. 南京中医药大学药学院,江苏 南京 210023;南京中医药大学 江苏省中医外用药开发与应用工程研究中心,江苏 南京 210023
- Publication Type:Journal Article
- Keywords:
essential oils from traditional Chinese medicine with hot property;
skin cytotoxicity;
percutaneous penetration enhance-ment effect;
oil-water partition coefficient
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(1):58-65
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study regularity of different components whose skin permeability is enhanced by essential oils(EOs)from traditional Chinese medicine(TCM)with hot property.METHODS Five EOs from TCM with hot property,namely Galangal oil,Dried Ginger oil,Cinnamon oil,Pepper oil,and Evodia oil were prepared and used in further studies.The in vitro skin cytotoxici-ty of these EOs and chemical penetration enhancer(PE)Azone were compared.HPLC method was established to determine 9 TCM components that are usually used in permeation studies.And the in vitro permeation experiments were carried out using the modified Franz diffusion cell method to evaluate the penetration enhancement effects of five EOs.RESULTS The cytotoxicity test revealed the IC50 value of EOs was 3.63-8.15 times of that of Azone,the classical chemical PE.HPLC method showed perfect specificity and 9 TCM components performed well in linear relationship,precision,repeatability,stability,and average recovery rate.The results of multiple linear regression showed a significant association between the penetration enhancement effects of EOs from TCM with hot prop-erty and log P values of the TCM components.EOs from TCM with hot property showed satisfactory penetration enhancement effects for hydrophobic components with log P values in the range of 2.6-3.5,e.g.resveratrol,tetrahydropalmatine and quercetin.CONCLU-SION EOs from TCM with hot property should be reasonably selected as PE according to the oil-water partition coefficient of the in-gredients.
