The expression of plasma lncRNA CEBPA-AS1 and miR-139-5p in patients with acute cerebral infarction and their correlation with cognitive dysfunction
10.11958/20241422
- VernacularTitle:急性脑梗死患者血浆LncRNA CEBPA-AS1、miR-139-5p表达及与认知功能障碍的相关性分析
- Author:
Peiyuan LI
1
;
Gang WANG
1
;
Junfeng SHI
1
Author Information
1. 南阳南石医院神经内科(邮编 473001)
- Publication Type:Journal Article
- Keywords:
cognitive dysfunction;
cerebral infarction;
acute disease;
long non coding RNA CEBPA-AS1;
miR-139-5p
- From:
Tianjin Medical Journal
2025;53(1):75-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect levels of plasma long non coding RNA(lncRNA)CCAAT enhancer binding protein alpha antisense 1(CEBPA-AS1)and microRNA-139-5p(miR-139-5p)in patients with acute cerebral infarction(ACI),and to explore their relationship with cognitive dysfunction in ACI patients.Methods A total of 132 ACI patients treated in our hospital were included for the study.The Montreal Cognitive Assessment Scale(MoCA)was used to evaluate the cognitive function of ACI patients,and they were diveded into the cognitive dysfunction group(n=63)and the normal cognitive function group(n=69).The general data of the two groups were compared.The qRT-PCR method was applied to measure plasma levels of lncRNA CEBPA-AS1 and miR-139-5p in ACI patients.Pearson method was applied to analyze the correlation between plasma lncRNA CEBPA-AS1 and miR-139-5p in ACI patients.Multivariate Logistic regression was applied to analyze factors influencing cognitive dysfunction in ACI patients.Receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of plasma lncRNA CEBPA-AS1 and miR-139-5p for cognitive dysfunction in ACI patients.Results Compared with the normal cognitive function group,the plasma lncRNA CEBPA-AS1 was higher and the miR-139-5p was lower in the cognitive dysfunction group(P＜0.05).Correlation analysis showed that there was a negative correlation between lncRNA CEBPA-AS1 and miR-139-5p(r=-0.462,P＜0.01).Multivariate analysis showed that high school education or below,decreased plasma miR-139-5p,and increased lncRNA CEBPA-AS1 were risk factors for cognitive dysfunction in ACI patients(P＜0.05).The area under the curve(AUC)of lncRNA CEBPA-AS1 and miR-139-5p in the diagnosis of cognitive dysfunction in ACI patients was 0.865 and 0.798,respectively.The combined diagnostic efficacy of the two(AUC=0.912)was better than single index.Conclusion The plasma lncRNA CEBPA-AS1 is increased and the plasma miR-139-5p is decreased in patients with ACI combined with cognitive dysfunction,and both are influencing factors for cognitive dysfunction in ACI patients,and the combined diagnostic efficacy is high.
