Progress of macrophage regulation mechanism in acute renal injury
- VernacularTitle:急性肾损伤中巨噬细胞调控机制进展
- Author:
Yuxin DUAN
1
;
Yanni ZHANG
1
;
Yi BAI
1
;
Jinyao YU
1
;
Jiayi SUN
1
;
Zejie WANG
1
;
Ling LI
1
;
Qifa YE
1
Author Information
- Publication Type:Journal Article
- Keywords: acute kidney injury; macrophage-sensing mediators; macrophage-derived mediators; signal pathway
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(1):110-117
- CountryChina
- Language:Chinese
- Abstract: Acute kidney injury(AKI)is a syn-drome characterized by rapid decline in renal excre-tory function.Its pathogenesis is still unclear.Stud-ies have shown that macrophages are major play-ers in AKI inflammation,regulating tissue damage and regeneration repair.During AKI inflammation,macrophages can be activated into different func-tional phenotypes through molecular and signaling pathways,regulate different molecules and signal-ing pathways,and determine the progression of AKI.In this paper,the activation of macrophages and the molecular signaling pathways involved in the regulation of AKI in the past five years are re-viewed,and the mechanism of action of macro-phages in AKI is determined,which provides ideas for the study of macrophages as therapeutic tar-gets.
