Safety of breast-conserving surgery in young breast cancer patients with tumors near the nipple-areola complex
10.3760/cma.j.cn115807-20231110-00144
- VernacularTitle:癌灶近乳头乳晕复合体的年轻乳腺癌患者保乳术安全性分析
- Author:
Zongyuan WU
1
;
Yuhang XU
1
;
Meiying SHEN
1
;
Yuxia CHEN
1
Author Information
1. 茂名市人民医院乳腺科，茂名 525000
- Publication Type:Journal Article
- Keywords:
Young breast cancer;
Tumor near NAC;
Post-neoadjuvant treatment;
Breast-conserving surgery
- From:
Chinese Journal of Endocrine Surgery
2025;19(5):656-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the feasibility and safety of breast-conserving surgery for young women with breast cancer whose tumor is close to nipple areola complex after neoadjuvant therapy.Methods:Young female breast cancer patients treated at Maoming People’s Hospital from Jan. 2016 to Jan. 2022 were selected. The inclusion criteria were primary solitary tumors located within ≤2 cm from the areola margin (excluding carcinoma in situ, nipple discharge, and Paget’s disease), tumor diameter ranging from 1 to 3 cm, and no abnormal adhesion between the tumor and the areola, breast skin, or chest wall. A total of 87 patients were enrolled, including 44 who underwent NAC-sparing breast-conserving surgery (NAC-preservation group) and 43 who underwent breast-conserving surgery without NAC preservation (non-NAC-preservation group). All patients received postoperative radiotherapy and continued systemic therapy. Local recurrence and distant metastasis were compared between the two groups.Results:No statistically significant differences were observed between the two groups in pre-neoadjuvant therapy tumor stage, tumor location, tumor diameter, lymph node metastasis, or molecular subtype ( χ2=0.22, 0.67, 0.80, 1.25, 1.76, respectively; P>0.05). At the 2-year postoperative follow-up, no local recurrence was detected in either group. Distant metastasis occurred in one case in the NAC-preservation group and three cases in the non-NAC-preservation group, with no statistically significant difference (2.27% vs. 6.98%, χ2=1.097, P=0.295) . Conclusions:This study, to some extent, validates the feasibility of both patient groups undergoing breast-conserving surgery with or without NAC preservation after neoadjuvant therapy, in young breast cancer patients with tumors located near the nipple areola complex. Routine NAC excision does not improve therapeutic outcomes.
