Immune mechanism of epileptogenesis and therapeutic strategies
10.3969/j.issn.1000-484X.2025.11.042
- VernacularTitle:癫痫发病的免疫学机制及治疗策略
- Author:
Yi LIU
1
;
Hao HE
;
Shao GONG
;
Guanglei WANG
Author Information
1. 泰安市妇幼保健院儿内科,泰安 271000
- Publication Type:Journal Article
- Keywords:
Immunologic;
Neuroinflammatory;
Epilepsy;
Anti-epileptic therapy
- From:
Chinese Journal of Immunology
2025;41(11):2808-2811
- CountryChina
- Language:Chinese
-
Abstract:
In the pathogenesis of many neurological diseases such as epilepsy,immune responses and neuroinflammation play a key role and provide new directions for treatment.In the era of personalized medicine,with the reduction of anti-epileptic treatment resources,there is an increasing focus on the application of neuroimmunomodulators or anti-inflammatory treatments in epilepsy patients.Therefore,this article reviews the latest progress in the epileptogenic mechanisms related to immune activation or neuroin-flammation,with particular attention to current and potential new treatments for epilepsy in the future.Neuroinflammation can lead to various types of epilepsy,including structural,infectious,post-traumatic,autoimmune and hereditary epilepsy.In recent years,some emerging studies have identified multiple major molecular pathways in the neuroinflammatory process,which may become future thera-peutic targets for epilepsy.A variety of drugs that are currently known or under development have been proven to have the ability to inhibit or regulate immune or neuroinflammatory molecules in epilepsy,and some of these drugs are expected to become new options for antiepileptic treatment.
