Different preoperative management of initially diagnosed breast cancer patients with uncontrolled hyperthyroidism: 2 cases analysis and reference review
10.3760/cma.j.cn115807-20250525-00142
- VernacularTitle:首诊乳腺癌伴甲状腺功能亢进术前处理分析
- Author:
Yuanyin XI
1
;
Pu QIU
1
;
Lingquan KONG
1
;
Yixiao FENG
1
;
Yuanyuan WANG
1
;
Hongyuan LI
1
;
Guosheng REN
1
;
Kainan WU
1
Author Information
1. 重庆医科大学附属第一医院乳腺甲状腺外科，重庆 400016
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Hyperthyroidism;
Thyroid crisis;
Neoadjuvant therapy
- From:
Chinese Journal of Endocrine Surgery
2025;19(4):623-624
- CountryChina
- Language:Chinese
-
Abstract:
Patients with initially diagnosed breast cancer and uncontrolled hyperthyroidism are at high risk of perioperative thyroid crisis. This article reports two cases of early-stage breast cancer initially diagnosed concurrently with uncontrolled primary hyperthyroidism. In Case 1, the patient received neoadjuvant chemotherapy to control breast cancer progression while concurrently taking antithyroid drugs to manage hyperthyroidism. Hyperthyroidism was controlled during chemotherapy, and the patient successfully underwent surgery after neoadjuvant chemotherapy. Case 2 involved recurrent primary hyperthyroidism with leukopenia after antithyroid drug therapy. Since leukopenia is a relative contraindication for antithyroid drugs, the patient underwent radioactive iodine therapy (iodine-131) and endocrine therapy for one month before proceeding with breast cancer surgery. Through a literature review, this article analyzes preoperative management strategies for uncontrolled hyperthyroidism in initially diagnosed breast cancer patients, emphasizing the importance of normalizing thyroid function to prevent thyroid crisis and reduce perioperative risks.
