Correlation of the expression of ILT4 and CD147 with tumor immunoinfiltration and prognosis in lung adenocarcinoma
- VernacularTitle:肺腺癌中ILT4、CD147表达与肿瘤免疫浸润及预后的相关性研究
- Author:
Jia-hui LI
1
;
Yi-ze GUO
;
Wen HU
;
Li ZHANG
Author Information
- Publication Type:Journal Article
- Keywords: lung adenocarcinoma; ILT4; CD147; tumor microenvironment; immunoinfiltration; prognosis
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(11):993-998
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the expression of ILT4 and CD147 in lung adenocarcinoma and their relationships with tumor immunoinfiltration and prognosis of patients.Methods The specimens of cancer tissues and adjacent tissues of 134 patients with lung adenocarcinoma who underwent surgical treatment at our hospital from January to December 2024 were collected,and a retrospective analysis was conducted on the clinical data of the patients.The protein and mRNA expression of ILT4 and CD147 in different tissues were detected by immunohistochemistry and qRT-PCR,respectively.The correlations of the expression of ILT4 and CD147 with the clinicopatho-logical characteristics of lung adenocarcinoma were analyzed.The expression of ILT4 and CD147 in pan-cancer tissues were retrieved based on the GEPIA2 database,and their relationships with the prognosis of lung adenocarcinoma were analyzed.The correlations of the expression of ILT4 and CD147 with the infiltration of 6 kinds of immune cells in lung adenocarcinoma samples were analyzed based on TIMER database.Results The protein positive rates and mRNA expression levels of ILT4 and CD147 in lung adenocarcinoma tissues were significantly higher than those in adjacent tissues(P<0.05).The analysis of GEPIA database showed that ILT4 and CD147 upregulated in various tumors,and the expression levels of ILT4 and CD147 in lung adenocarcinoma tissues were both higher than those in unpaired adjacent tissues.The expression of ILT4 protein was closely related to the TNM stage and lymph node metastasis of lung adenocarcinoma(P<0.05);the expression of CD147 protein was correlated with TNM stage,lymph node metastasis and degree of differentiation(P<0.05).The analysis of GEPIA database showed that the patients with high expression of ILT4 and CD147 had lower overall survival rates than those with low expression(Log-rank P=0.000 58,0.002 6).The analysis of the TIMER database showed that the expression of ILT4 was negatively correlated with the infiltration of macrophages,neutrophils and dendritic cells(P<0.05);the expression of CD147 was negatively correlated with the infiltration of B cells,CD4+T cells and dendritic cells(P<0.05).Conclusion ILT4 and CD147 are highly expressed in lung adenocarcinoma tissues,which are related to clinicopathological features,prognosis and immunoinfiltration of patients.They may be the potential markers for prognosis evaluation and immunotherapeutic targets of patients with lung adenocarcinoma.
