The Theoretical Conception and Realization Path of Animal Model Evaluation of Emotional Disease Based on Syndrome Ele-ment Differentiation Theory
10.14148/j.issn.1672-0482.2025.0026
- VernacularTitle:基于证素辨证理论的情志病证动物模型评价的理论构想及实现路径探究
- Author:
Sheng WEI
1
;
Zifa LI
1
;
Xiwen GENG
1
;
Hao ZHANG
1
;
Xinyu WANG
1
;
Minghui HU
1
Author Information
1. 山东中医药大学中医药与脑科学交叉学科研究中心,山东 济南 250355;中医药防治重大脑疾病山东省工程研究中心,山东 济南 250355;济南市中医药重大脑疾病防治重点实验室,山东 济南 250355
- Publication Type:Journal Article
- Keywords:
syndrome element differentiation theory;
animal model of emotional disease;
theoretical conception;
implementation path
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
At present,the main reason for the lagging development of emotional disease theory and the backward development of targeted drugs is the lack of suitable and effective animal models,and model evaluation is the key and difficult point in the preparation of emotional disease animal models.The theory of syndrome element differentiation in traditional Chinese medicine is closely matched with the theory of behavioral elements in animal behavior,which is expected to bring theoretical changes and methodological progress in related fields.Based on this background,this paper systematically sorted out and clarified the theoretical conception of animal model e-valuation of emotional diseases:guided by the thinking mode of syndrome differentiation theory of TCM,an attempt was made to estab-lish a complete model evaluation system.It also pointed out the realization path of animal model evaluation of emotional disease based on syndrome element differentiation theory:collection of behavioral elements in natural state and analysis of time sequence,phenotypic identification of abnormal behaviors under stress state,and equivalent transformation of model animal syndrome discrimination.
