Analysis of prognostic factors of ultrasound-guided microwave ablation for papillary thyroid carcinoma
10.3760/cma.j.cn115807-20240831-00283
- VernacularTitle:超声引导下微波消融治疗甲状腺乳头状癌预后的影响因素分析
- Author:
Weiwei LU
1
;
Danqing LIU
1
;
Xiaoyue WEI
1
Author Information
1. 商丘市第一人民医院超声科，商丘 476000
- Publication Type:Journal Article
- Keywords:
Ultrasound;
Microwave ablation;
Papillary thyroid carcinoma
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic factors of ultrasound-guided microwave ablation (MWA) in the treatment of papillary thyroid carcinoma.Methods:The medical records of 97 patients with papillary thyroid carcinoma treated in Shangqiu First People’s Hospital from Jun. 2019 to Dec. 2021 were retrospectively analyzed.All of them were treated with ultrasount-guided MWA,including 38 males and 59 females,aged (48.24±7.86) years. The patients were followed up until Oct. 2024, and the prognosis of the patients was statistically analyzed.According to whether there was new lymph node metastasis or recurrence,the patients were divided into good prognosis group and poor prognosis group.Statistical software SPSS26.0 was used to process the baseline data of the two groups,and the factors affecting the prognosis of papillary thyroid carcinoma were analyzed.Results:Among 97 patients,3 cases were lost to follow-up,73 cases were in good prognosis group and 21 cases were in poor prognosis group.The incidence of multiple lesions,diameter 5-10 mm,close envelope and BRAFV600E mutations in poor prognosis group were 52.38%, 76.19%, 61.90% and 57.14%, respectively, which were higher than 27.40%, 49.32%, 20.55% and 31.51% in good prognosis group ( P<0.05) .TSH level of (2.94±0.61) mlU/L was higher than that of good prognosis group (2.67±0.52) mlU/L ( P<0.05) .Multivariate Logistic regression analysis showed that multiple lesions ( OR=2.915,95%CI:1.073-7.916) ,diameter 5-10mm ( OR=3.289,95% CI:1.090-9.920) , close to the envelope ( OR=6.283,95% CI:2.203-17.917) and BRAFV600E mutations ( OR=2.899,95% CI:1.071-7.843) were independent risk factors for poor prognosis in ultrasound-guided MWA treatment of isthmic papillary carcinoma ( P<0.05) .The ROC curve showed that the AUC value of the four combinations was 0.895,which was significantly higher than the number of lesions (0.625) , tumor size (0.634) , close envelope (0.707) and BRAFV600E mutation (0.628) . Conclusion:Multiple lesions,5-10mm in diameter,close envelope and BRAFV600E mutation are the factors affecting the poor prognosis of patients with isthmic papillary carcinoma treated with ultrasound-guided MWA,and the combination of the four factors is more effective in predicting the prognosis of patients with papillary thyroid carcinoma.
