Application of STING pathway activated by nanodrug delivery system in tumor immunotherapy
10.3969/j.issn.1000-484X.2025.11.041
- VernacularTitle:纳米释药系统激活STING通路在肿瘤免疫治疗中的应用
- Author:
Shuya ZHANG
1
;
Haining LIU
;
Shasha SUN
;
Zhaoyu LU
;
Feifei SHEN
;
Pei ZHANG
Author Information
1. 洛阳职业技术学院医学技术学院,洛阳 471099
- Publication Type:Journal Article
- Keywords:
Tumor immunotherapy;
cGAS-STING;
Nano-drug delivery system;
STING agonist;
DNA damage
- From:
Chinese Journal of Immunology
2025;41(11):2795-2807
- CountryChina
- Language:Chinese
-
Abstract:
Tumor immunotherapy has attracted worldwide attention in cancer treatment because of its obvious advantages such as strong specificity and long curative effect.It is found that activation of STING signaling pathway in cells is one of directions to effec-tively realize tumor immunotherapy.However,due to low response rate of related drugs,difficult degradation,certain toxic and side effects,its clinical application has been seriously hindered.Nano-drug delivery system can achieve targeted drug delivery,improve drug stability,delivery rate,osmotic effect and long-term retention effect,reduce drug side effects,and show significant advantages in tumor immunotherapy.In this paper,research progress of nano-drug delivery system activating STING pathway in tumor immunother-apy in recent years is reviewed,and many nano-drug delivery systems that can activate STING signal pathway and their application ex-amples after loading drugs are listed,including nucleotide-based drug delivery system,non-nucleotide-based drug delivery system and metal-based drug delivery system,providing reference for application of nano-drugs in tumor immunotherapy.
