Effects of low opioid dose afentanil induced laryngeal mask intubation on postoperative cognition and mood in patients undergoing breast cancer surgery
10.3760/cma.j.cn115807-20241226-00393
- VernacularTitle:低阿片剂量阿芬太尼诱导喉罩插管对乳腺癌手术患者术后认知和情绪的影响
- Author:
Jie ZHOU
1
;
Xingcen WANG
1
;
Huijuan HUANG
1
;
Xianping HUANG
1
Author Information
1. 杭州市第三人民医院麻醉科，杭州 310000
- Publication Type:Journal Article
- Keywords:
Low opioid dose;
Afentanil;
Breast cancer surgery;
Cognitive function;
Emotional disturbance
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):182-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application of low opioid dose afentanil induced laryngeal mask intubation in patients undergoing breast cancer surgery and its effects on postoperative cognition and mood.Methods:A retrospective study was conducted on 80 patients with radical mastectomy admitted to our hospital from Jan. 2020 to Jun. 2024. Clinical data of the patients were statistically analyzed, and they were divided into control group (47 cases with sufentanil as intravenous sedative drug) and observation group (33 cases with afentanil as intravenous sedative drug) according to different anesthesia methods. The scores of MMSE and Hospital Anxiety and Depression Scale (HAD) before anesthesia and 24 and 48h after anesthesia were compared between the two groups, and the observation group was divided into different subgroups with different doses of afentanil, and the changes of MMSE and HAD scores were observed.Results:There was no significant difference in age, cancer type, clinical symptoms and BMI between 2 groups ( t=0.12, 0.25, P=0.902, 0.801, χ 2=0.05, 2.08, 0.30, 1.69, 0.32, 0.05, 0.08, P=0.978, 0.149, 0.586, 0.193, 0.571, 0.820, 0.960) . At 24h and 48h after surgery, the MMSE score of the 2 groups was significantly decreased, but the score at 48h after surgery was higher than that at 24h after surgery. Meanwhile, the score at 24h after surgery of the observation group) and the score at 48h after surgery, was higher than that of the control group, and the difference was statistically significant ( t=4.15, 4.48, P<0.001) . At 24h and 48h after surgery, the HAD score of the two groups was significantly increased, and the HAD score of the control group at 48h after surgery was significantly higher than that of the control group at 24h after surgery, but the observation group was significantly lower than the control group at 48h, with statistical significance ( t=6.22, P<0.001) . At the induction stage of anesthesia, MMSE scores were significantly higher in the 50-75 μg/kg group than in the 25-50μg/kg group, and HAD scores were significantly lower 48 hours after surgery. At the same time, the MMSE score of 0.5-1.0 μg·kg -1·min -1 group was significantly higher than that of 1.0-2.0 μg·kg -1·min -1 group 48h after anesthesia maintenance, and the HAD score was significantly lower than that of 1.0-2.0 μg·kg -1·min -1 group 48h after anesthesia, with statistical significance ( t=8.80, P<0.001) . Conclusion:Afentanil induced laryngeal mask intubation has high application value in breast cancer surgery patients, which can effectively restore patients' cognitive ability and relieve patients' anxiety, and the effect of low-dose intervention is more obvious, which is worthy of clinical promotion and application.
