Research progress on mechanism of interferon regulation of JAK/STAT pathway in HIV-1 infection
10.3969/j.issn.1000-484X.2025.11.038
- VernacularTitle:干扰素调控JAK/STAT通路在HIV-1感染中的作用机制研究进展
- Author:
Qing LI
1
;
Long FENG
;
Jingyi ZHANG
;
Yuxuan GENG
;
Mengyuan SHI
;
Qingya LI
;
Wentao GUO
;
Haiyan ZHANG
;
Jiawen LYU
Author Information
1. 河南中医药大学医学院,郑州 450046
- Publication Type:Journal Article
- Keywords:
Interferon;
JAK;
STAT;
Human immunodeficiency virus
- From:
Chinese Journal of Immunology
2025;41(11):2779-2783,2789
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus(HIV)is the pathogen of acquired immune deficiency syndrome(AIDS).The vi-rus is a highly contagious and highly pathogenic disease caused by the virus attacking the human immune system,which remains a ma-jor global public health problem.Interferon(IFN)is a key cytokine with antiviral and cell-regulatory properties,involved in functions such as cell proliferation,innate and adaptive immune responses.The JAK/STAT signaling pathway is a signal transduction pathway stimulated by cytokines that is involved in many important biological processes such as cell proliferation,differentiation,apoptosis,and immune regulation.With the further in-depth research on AIDS,it has been revealed that IFN and the JAK/STAT pathway play crucial roles in the activation and replication of HIV-1 in target cells.This paper summarizes the structure,signal transduction,and regulatory mechanisms of IFN and the JAK/STAT pathway,and explores the mechanism of IFN-regulated JAK/STAT signaling path-way in HIV-1.It is expected to provide new treatment strategies for the clinical treatment of AIDS.
