Research progress of IL-18 and IL-37b in blood basophil activation of patients with allergic rhinitis
10.3969/j.issn.1000-484X.2025.11.037
- VernacularTitle:IL-18和IL-37b在过敏性鼻炎患者血液嗜碱性粒细胞活化中的作用研究进展
- Author:
Junling WANG
1
;
Mengmeng ZHAN
;
Enming DU
;
Siqin WANG
;
Shaoheng HE
Author Information
1. 河南省人民医院过敏反应科,郑州 450003;锦州医科大学附属第一医院变态反应与临床免疫研究中心,锦州 121001
- Publication Type:Journal Article
- Keywords:
Allergic rhinitis;
Basophil activation;
IL-18;
IL-37b
- From:
Chinese Journal of Immunology
2025;41(11):2774-2778
- CountryChina
- Language:Chinese
-
Abstract:
Allergic rhinitis(AR)is the most common airway allergic diseases.Basophils are the classical effector cells in allergy,including AR:Both IgE and non-IgE mediated methods can activate basophils during allergic reactions and induce basophils to release various inflammatory mediators,which is accompanied by changes in the expression of multiple membrane proteins,and ulti-mately leading to the clinical manifestations of allergic diseases.IL-18 may be involved in the pathogenesis of AR by directly inducing basophil activation and inflammation response via binding to its receptor IL-18Rα.Nevertheless,the binding of IL-37b to IL-18Rα initiates the downstream anti-inflammatory signals,thus inhibiting inflammation reaction in AR.Therefore,understanding the role and mechanism of IL-18 and IL-37b in the activation of blood basophils of AR patients is of great significance for the pathogenesis,treat-ment of AR and the development of related biological agents.
