Role of m6A methylation modifications in pathogenesis of SLE
10.3969/j.issn.1000-484X.2025.11.035
- VernacularTitle:m6A甲基化修饰在SLE发病机制中的作用
- Author:
Yawen ZHU
1
;
Yuanyuan CHENG
1
;
Ai QIAN
1
;
Chuanbing HUANG
1
Author Information
1. 安徽中医药大学第一附属医院,合肥 230031
- Publication Type:Journal Article
- Keywords:
SLE;
m6A methylation modification;
Pathogenesis
- From:
Chinese Journal of Immunology
2025;41(11):2764-2768
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine(m6A)methylation modification is the most common post-transcriptional modification in eukaryotic RNA and plays an important role in RNA metabolism,immune cell stability,and immunomodulation.Systemic lupus erythematosus(SLE)is a diffuse,systemic autoimmune disease caused by the binding of autoantibodies to corresponding autoimmune antigens to form immune complex deposits.The pathogenesis of SLE is complex.With the continuous deepening of research,it has been discovered in recent years that m6A methylation modification can participate in the occurrence of SLE by regulating immune cells and promote the development of SLE from aspects such as oxidative stress and inflammatory response.This article reviews the research progress on the three proteins modified by m6A methylation and their relationship with the pathogenesis of SLE.
