Investigation and analysis of HLA antibody carrying status among female blood donors with a history of pregnancy in Shandong region
10.13431/j.cnki.immunol.j.20240103
- VernacularTitle:山东地区有妊娠史女性献血者HLA抗体携带情况的调查分析
- Author:
Jingru SHAO
1
;
Yan GU
;
Yan LIU
;
Yingfang PAN
;
Xiangmin NIE
;
Wenchao LI
Author Information
1. 250000 济南,山东省血液中心
- Publication Type:Journal Article
- Keywords:
Female blood donor;
HLA antibodies;
Pregnancy history;
Shandong region
- From:
Immunological Journal
2024;40(9):739-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the positive rate of HLA-Ⅰ or/and HLA-Ⅱ antibody in female blood donors with a history of pregnancy in Shandong region,with an aim of exploring the significance of HLA antibody testing in reducing clinical platelet transfusion adverse reactions,and providing data support for safe blood transfusion and rational use of blood products.Method Flow cytometry microbead method was used to detect HLA-Ⅰ and HLA-Ⅱ antibodies in 186 samples included in this study.Result Among 186 female blood donors with pregnancy history,77 were detected as positive for HLA-Ⅰ class antibodies(41.4％),41 cases were HLA-Ⅱ positive(22.0％),92 cases were positive for HLA-Ⅰ or/and HLA-Ⅱ antibodies(49.5％).Conclusion A preliminary investigation has conducted on the distribution of HLA antibodies among female blood donors with a history of pregnancy in the local area,and the HLA antibody positivity rate is as high as 49.5％.The results of this study provide a certain data basis for the establishment of preventive measures for transfusion immune related complications caused by blood products and HLA antibodies in a reasonable manner.
