Interweaving infection and immunity:Advances in ANCA-associated vasculitis research

VernacularTitle:感染与免疫交织:ANCA相关性血管炎研究进展
Author: Ting WANG ¹ ; Jie LI ; Fenglin ZHU ; Lamei ZHOU
Author Information

1. 重庆市松山医院,重庆市第十三人民医院,重庆 400016
Publication Type:Journal Article
Keywords: ANCA-associated vasculitis; Infection; Immunity
From: Chinese Journal of Immunology 2025;41(11):2784-2789
CountryChina
Language:Chinese
Abstract: This review aims to provide clinical guidance for the diagnosis and treatment of ANCA-associated vasculitis(AAV)by summarizing recent advances in the research on the immunological aspects of infection and AAV.Literatures are retrieved from PubMed,CNKI,Wanfang and other databases.The search terms are set as"ANCA","vasculitis","infection"and"immunity".The existing literatures are reviewed and analyzed.Infection plays a crucial role throughout the course of AAV,affecting onset,disease activity,treatment and prognosis.Infections are not only significant triggers for the onset of AAV,but also factors that precipitate relapses.Additionally,the immunosuppression involved in AAV treatment increases susceptibility to infections,which can exacerbate AAV.Concurrent infections have become a leading cause of death in AAV patients.The interplay of infection,molecular mimicry,and genetic cross-reactivity represents a primary pathogenic mechanism in AAV.Reducing infection-induced immune responses has a posi-tive implication in the management of AAV.