Advances in mechanism of astrocyte-microglia crosstalk in neuroinflammatory diseases
10.3969/j.issn.1000-484X.2025.11.034
- VernacularTitle:神经炎症疾病中星形胶质细胞和小胶质细胞互作机制的研究进展
- Author:
Chengcheng ZHANG
1
;
Xinyu ZHANG
;
Lu LIU
Author Information
1. 首都医科大学附属北京中医医院针灸中心,针灸神经调控北京市重点实验室,北京 100010
- Publication Type:Journal Article
- Keywords:
Neuroinflammation;
Microglia;
Astrocyte;
Interaction;
Research progress
- From:
Chinese Journal of Immunology
2025;41(11):2756-2763
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammation refers to the innate and adaptive immune responses initiated by various immune cells releasing inflammatory mediators after harmful injury.Neuroinflammatory diseases are diseases caused by inflammatory reactions in the nervous system.Astrocytes are the most common glial cell type in central nervous system.Microglia,as immune cells,have ability to monitor and clear pathological damage.Recent studies have shown that there are complex interactions between astrocytes and microglia,which together participate in the progression of neuroinflammatory diseases and play a key regulatory role.This review briefly introduces the interaction mechanisms between astrocytes and microglia in neuroinflammatory diseases,including Alzheimer's disease,Parkinson's disease,multiple sclerosis,amyotrophic lateral sclerosis,Huntington's disease and migraine,aims to provide new ideas and methods for the treatment of neuroinflammatory diseases.
