Correlation among preoperative serum CA153, CA125 and postoperative recovery, prognosis of patients with breast cancer
10.3760/cma.j.cn115807-20240919-00296
- VernacularTitle:术前血清CA153、CA125与乳腺癌患者术后恢复及预后的相关性研究
- Author:
Gongpu CHEN
1
;
Kuojun REN
1
;
Shikai HONG
1
Author Information
1. 安徽省肿瘤医院乳腺外科，合肥 230001
- Publication Type:Journal Article
- Keywords:
Carbohydrate antigen 153;
Carbohydrate antigen 125;
Breast cancer;
Postoperative recurrenc;
Lymph node metastasis
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):159-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation among preoperative serum carbohydrate antigen (CA) 153, CA125 and postoperative recovery, prognosis of patients with breast cancer.Methods:A total of 126 breast cancer patients admitted to our hospital from Jan. 2022 to Jan. 2024 undergoing surgical treatment were chosen as the observation group, and 50 healthy subjects were chosen as the control group during the same period. Serum CA153 and CA125 levels in the two groups were detected. The postoperative recovery of patients in the observation group was analyzed, and the correlation among postoperative recovery indexes and preoperative serum CA153, CA125 was analyzed. Patients were followed up for 6 months after surgery, and were divided into the good prognosis group and the poor prognosis group according to whether there was tumor recurrence or metastasis. Logistic regression was used to analyze the correlation among prognosis, serum CA153, CA125 levels and clinicopathological parameters of patients with breast cancer.Results:The levels of serum CA153 and CA125 in the observation group were significantly higher than those in the control group ( t=22.31, 18.82, P<0.05) ; The first time of anal exhaust, the first time of getting out of bed and the time of hospitalization after breast cancer surgery were (11.26±2.16) h, (23.30±3.54) h and (8.26±2.20) d, respectively; Postoperative recovery indexes were significantly positively correlated with preoperative serum CA153 and CA125 levels ( r=0.33, 0.45, 0.34, 0.41, 0.36, 0.50, P<0.05) ; After 6 months of follow-up, 43 patients had recurrence and metastasis, accounting for 12.20%, which could be divided into good prognosis group ( n=111) and poor prognosis group ( n=15) . Preoperative serum CA153 and CA125 levels in good prognosis group were significantly lower than those in poor prognosis group ( t=3.75, 3.61, P<0.05) ; There were no significant differences in age, menstrual status or pathological type between the good prognosis group and the poor prognosis group ( χ2=0.45, 1.49, 0.34, P>0.05) , but there were significant differences in tumor diameter, TNM stage and lymph node metastasis between the two groups ( χ2=4.38, 5.38, 5.74, P<0.05) ; Logistic regression analysis showed that CA153 ( OR=4.669, 95% CI=1.537-14.187, P<0.05) , CA125 ( OR=2.517, 95% CI=1.622-3.904, P<0.05) , TNM stage ( OR=2.942, 95% CI=1.299-6.661, P<0.05) and lymph node metastasis ( OR=3.622, 95% CI=1.242-10.561, P<0.05) were risk factors for postoperative recurrence and metastasis of breast cancer ( P<0.05) . Conclusions:Preoperative serum CA153 and CA125 levels in patients with breast cancer are related to postoperative recovery and prognosis.
