Dynamic changes of CD4+T lymphocytes in peripheral blood of patients with bronchial asthma at different periods and its correlation with control level
10.3969/j.issn.1000-484X.2025.11.024
- VernacularTitle:不同时期支气管哮喘患者外周血中CD4+T淋巴细胞动态变化及其与控制水平的相关性
- Author:
Wanting SUN
1
;
Xiaoyang LIU
1
;
Fengmian ZHAO
1
;
Li ZHAO
1
;
Xiang ZHANG
1
Author Information
1. 首都医科大学附属北京积水潭医院呼吸与危重症医学科,北京 102208
- Publication Type:Journal Article
- Keywords:
T lymphocytes;
Bronchial asthma;
Peripheral blood;
Control level
- From:
Chinese Journal of Immunology
2025;41(11):2703-2707
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore dynamic changes of CD4+T lymphocytes in peripheral blood of patients with bronchial asthma at different periods and its correlation with control level.Methods:A total of 108 patients with bronchial asthma who received medical treatment in Beijing Jishuitan Hospital,Capital Medical University from September 2020 to October 2022 were selected as study objects,and CD4+T level in peripheral blood of patients with asthma at different periods were compared.According to control level,patients were divided into control group(n=68)and uncontrolled group(n=40).Factors affecting control level of patients with bronchial asthma were analyzed,and prediction model of column graph was constructed and evaluated.Results:CD4+T level in periph-eral blood of patients with acute attack of bronchial asthma was significantly lower than that in chronic duration stage and clinical control stage,CD8+T and CD3+T levels were significantly higher than that in chronic duration stage and clinical control stage(P<0.05).Allergic rhinitis,smoking history,acute respiratory tract infection and residential air pollution were uncontrolled risk factors of patients with bronchial asthma,CD4+T and regular use of inhaled corticosteroids were protective factors(P<0.05).The above indexes were used to construct a line chart model.After internal verification(Bootstrap resamplage 1 000 times),it was found that AUC of this model was 0.845(95%CI:0.734～0.885),sensitivity and specificity were 85.7%and 88.6%,respectively.Conclusion:CD4+T lymphocytes in peripheral blood of patients with acute asthma are significantly lower than patients with chronic asthma and healthy people.Allergic rhinitis,smoking history,acute respiratory tract infection and residential air pollution are uncontrolled risk factors of patients with bronchial asthma,CD4+T and regular use of inhaled corticosteroids are protective factors.
