Effect of tofacitinib combined with traditional DMARDs therapy on peripheral blood IL-22,IL-23 levels and Th22 cell subsets in patients with rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.11.025
- VernacularTitle:托法替布联合传统DMARDs治疗对类风湿关节炎患者外周血IL-22、IL-23及Th22细胞亚群的影响
- Author:
Jingxu WANG
1
;
Xiangzhuo ZHAO
1
;
Jingfang SHEN
1
Author Information
1. 邢台市人民医院,邢台 054001
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Tofacitinib;
Traditional DMARDs;
IL-22;
IL-23;
Th22 cell subsets
- From:
Chinese Journal of Immunology
2025;41(11):2708-2712
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore effects of tofacitinib combined with traditional disease modifying antirheumatic drugs(DMARDs)on peripheral blood IL-22,IL-23 and Th22 cell subsets in patients with rheumatoid arthritis(RA).Methods:Retrospec-tive analysis of clinical data of 100 RA patients admitted to Xingtai People's Hospital from December 2022 to December 2024.Patients were divided into conventional group(n=33,treated with traditional DMARDs),single group(n=34,treated with tofacitinib)and combination group(n=33,treated with tofacitinib combined with traditional DMARDs)by random number table method.Serum IL-22 and IL-23 levels,Th22 cell subsets proportion,recovery of joint function,disease improvement and adverse reactions were compared in three group.Results:After 3 months of treatment,IL-22,IL-23 and Th22 cell subsets proportion in three groups were decreased compared to before treatment,and combination group was significantly lower than conventional group and single group(P<0.05);levels of anti-CCP and RF in three groups were decreased compared to before treatment,and combined group was significantly lower than conventional group and single group(P<0.05);joint swelling frequency,number of tender joints,morning stiffness time and VAS scores in three groups were decreased compared to before treatment,and combination group was significantly lower than conven-tional group and single group(P<0.05);DAS28 scores and HAQ scores of three groups were decreased compared to before treatment,and combined group was significantly lower than conventional group and single group(P<0.05);there was no statistically significant difference in incidence of adverse reactions among three groups during treatment period(Z=0.290,P=0.865).Conclusion:Clinical effect of tofacitinib combined with traditional DMARDs in treatment of RA is significant,which can effectively reduce serum IL-22,IL-23 and autoantibodies levels,regulate Th22 cell subsets proportion,alleviate inflammatory reactions,and improve joint function.
