Relationship between folic acid and thyroid antibodies in early pregnancy and adverse pregnancy outcomes in pregnant women with hypothyroidism during pregnancy
10.3760/cma.j.cn115807-20240528-00182
- VernacularTitle:孕早期叶酸及甲状腺抗体与妊娠期甲减孕妇不良妊娠结局的关系
- Author:
Tongkui WANG
1
;
Xiuming SUN
1
;
Xiaoli WANG
1
;
Chunxiao ZHOU
1
;
Hongmin WANG
1
;
Xiaorong FU
1
;
Kun YANG
1
Author Information
1. 聊城市第二人民医院产科，聊城 252600
- Publication Type:Journal Article
- Keywords:
First trimester;
Hypothyroidism;
Folate;
Thyroid antibody;
Pregnancy period;
Predictive value;
Adverse pregnancy outcome
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):243-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between folate and thyroid antibody in early pregnancy and adverse pregnancy outcome in pregnant women with hypothyroidism during pregnancy.Methods:The data of 97 pregnant women with hypothyroidism from Jul. 2020 to Mar. 2023 in the Obstetrics Department of Liaocheng Second People’s Hospital were retrospectively analyzed. The levels of folate, thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) were detected in the first trimester. According to whether adverse pregnancy outcome occurred in pregnant women with hypothyroidism during pregnancy, they were divided into occurrence group and non-occurrence group. The clinical data of the occurrence group and the non-occurrence group were compared. Logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in pregnant women with hypothyroidism during pregnancy, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of folic acid, TGAb, TPOAb and their combination on adverse pregnancy outcomes in pregnant women with hypothyroidism during pregnancy.Results:Among 97 pregnant women, the incidence of adverse pregnancy outcome was 14.43% (14/97) .The folate level in the occurrence group was lower than non-occurrence group ( P<0.05) , and the TGAb and TPOAb levels in the occurrence group were higher than non-occurrence group ( P<0.05) . The occurrence group with alanine aminotransferase (ALT) , glutamine transpeptidase (GGT) and aspartate aminotransferase (AST) were all higher than non-occurrence group ( P<0.05) .The folate, TGAb, and TPOAb levels were factors influencing adverse pregnancy outcomes in pregnant women with hypothyroidism ( P<0.05) . The area under the curve (AUC) values of folate, TGAb, TPOAb and their combined prediction of adverse pregnancy outcomes in pregnant women with hypothyroidism during pregnancy were 0.804, 0.843, 0.799, 0.909 ( P<0.05) , while the combined three with AUC values were higher ( P<0.05) . Conclusion:The folate, TGAb and TPOAb levels in early pregnancy can be used to evaluate adverse pregnancy outcomes in hypothyroidism pregnant women, and the combination of the three has a higher evaluation value.
