Correlation analysis of thyroid function, vitamin D level and preterm birth during pregnancy
10.3760/cma.j.cn115807-20240701-00223
- VernacularTitle:妊娠期甲状腺功能、维生素D水平与早产的相关性分析
- Author:
Feining NAN
1
;
Jianfang SUN
Author Information
1. 西北大学第一医院内分泌科，西安 710043
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Thyroid function;
Premature delivery;
Complications during pregnancy;
Hypothyroidism;
Pregnancy outcome
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):238-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between thyroid dysfunction, vitamin D level and adverse pregnancy outcome.Methods:From Apr. 2022 to Jun. 2023, among the pregnant women who were regularly examined and followed up to delivery in our hospital, 85 cases of hypothyroidism during pregnancy were selected as hypothyroidism group and 92 cases of normal thyroid function were selected as control group. Clinical characteristics of the two groups were compared to analyze the relationship between thyroid function and pregnancy outcome;The patients were divided into two groups according to preterm birth or not, and the influencing factors of preterm birth were analyzed.Results:TSH in hypothyroidism group was higher than that in control group, FT4 was lower than that in control group ( P<0.05) . The proportion of 25-OH-D normal patients in hypothyroidism group was lower than that in control group ( P<0.05) . Compared with the control group, gestational diabetes mellitus, gestational hypertension and preterm birth were increased in hypothyroidism group ( P<0.05) . The patients were divided into two groups according to preterm birth. The age and pre-pregnancy BMI of the preterm birth group were higher than those of the non-preterm birth group ( P<0.05) ; the proportion of elderly women, abnormal thyroid function, 25-OH-D deficiency, gestational hypertension and gestational diabetes in the preterm birth group was higher than that of the non-preterm birth group ( P<0.05) . Logistics regression analysis showed that thyroid dysfunction ( OR=2.632, 95% CI:1.572-4.864) , gestational hypertension ( OR=4.246, 95% CI: 2.247-7.953) , gestational diabetes ( OR=1.853, 95% CI:1.023-3.264) was an independent risk factor for preterm birth, and normal 25-OH-D ( OR=0.485, 95% CI:0.448-1.064) ,thyroid hormone therapy ( OR=2.850, 95% CI: 1.853-4.728) were protective factors for preterm birth ( P<0.05) . Conclusion:Abnormal thyroid function during pregnancy can increase the risk of preterm birth, and normal vitamin D levels and thyroid hormone therapy may help prevent preterm birth.
