Research progress on anti-inflammatory mechanism and safety of traditional Chinese medicine in the treatment of epilepsy
10.3760/cma.j.cn114015-20241109-00140
- VernacularTitle:中药治疗癫痫的抗炎作用机制及安全性研究进展
- Author:
Ya'nan HU
1
;
Wei YUE
;
Ling LING
;
Jinwei ZHANG
Author Information
1. 天津中医药大学中西医结合临床系，天津 301617
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Neuroinflammation diseases;
Treatment based on syndrome differentiation;
Drugs, Chinese herbal;
Active ingredients of traditional Chinese medici
- From:
Adverse Drug Reactions Journal
2025;27(4):238-244
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammatory response runs through the pathological process of epilepsy, and the regulation of proinflammatory factors such as (tumor necrosis factor-α, TNF-α), (interleukin, IL)-1β, IL-6 and Toll-like receptors 4/nuclear factor-kappa B signaling pathways may help improve epilepsy symptoms. Traditional Chinese medicines with anti-epileptic effects can be mainly divided into the following 6 categories: Pinggan Xifeng drugs (平肝息风药, liver-calming and wind-extinguishing herbs), Qingre drugs (清热药, heat-clearing drugs), Huatan drugs (化痰药, phlegm-relieving drugs), Huoxue Huayu drugs (活血化瘀药, circulation-promoting and stasis-removing drugs), Buxu drugs (补虚药, tonifying drugs), and Kaijiao drugs (开窍药, consciousness-restoring drugs). The active ingredients contained in these traditional Chinese medicines can play a therapeutic role in epilepsy treatment by regulating the release of key proinflammatory factors and inflammatory signaling pathways. Adverse reactions caused by Chinese patent medicines involve a variety of factors, which can be summarized into the process of medicinal materials preparation, the principle of traditional Chinese medicine compatibility, the accuracy of dialectical treatment, individual differences, etc. When using anti-epileptic Chinese medicine in clinical practice, it should be flexibly applied according to specific conditions to achieve the goal of precise treatment.
