Correlation of ultrasonic shear wave elastography, blood flow quantitative parameters and MYBL2 and MTA1 expression levels in breast cancer tissue
10.3760/cma.j.cn115807-20240402-0009
- VernacularTitle:超声剪切波弹性成像及血流定量参数与乳腺癌组织MYBL2和MTA1表达水平的相关性
- Author:
Changhong ZHANG
1
;
Liyuan TIAN
;
Zhihui YAN
;
Xiao DU
;
Yanping LI
Author Information
1. 济宁医学院附属医院健康管理中心，济宁 272029，
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Ultrasound examination;
Shear wave elastography;
MYB-associated protein B;
Metastasis-associated 1
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):853-858
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between ultrasonic SWE, blood flow quantitative parameters and the expression levels of MYB-associated protein B (MYBL2) and metastasis-associated 1 (MTA1) in breast cancer tissue.Methods:92 patients with breast cancer diagnosed and treated in our hospital from Jan. 2022 to Dec. 2023 were selected as the study objects, all of whom underwent ultrasonic SWE and blood flow imaging examination. Furthermore, the expression levels of MYBL2 and MTA1 in cancer tissues were detected, and the correlation between ultrasonic SWE and blood flow quantitative parameters and the expression levels of MYBL2 and MTA1 was analyzed.Results:The difference between maximum elastic modulus (Emax) and mean elastic modulus (E mean) in breast cancer patients with different lesion diameters and clinical stages was statistically significant (lesion diameters: t=4.561, 7.347; Clinical stage: t=4.218, 7.554, P<0.001) ; There were statistically significant differences in maximum blood flow velocity (V max), resistance index (RI), pulse index (PI) among breast cancer patients with different clinical stages, differentiation degrees and lymph node metastasis (clinical stage: t=7.055, 3.774, 3.877; Differentiation degree: F=26.830, 21.052, 20.412; Lymph node metastasis: t=7.425, 3.685, 4.956, P<0.001). There were statistically significant differences in E max, E mean, V max, RI and PI among breast cancer patients with different expression levels of MYBL2 and MTA1 (MYBL2: t=4.042, 10.672, 7.471, 6.137, 5.777; MTA1: t=5.968, 10.470, 8.098, 10.238, 7.565, P<0.001). By Spearman correlation analysis, E max and E mean were positively correlated with lesion diameter, clinical stage, MYBL2 expression level and MTA1 expression level ( P<0.001) ; V max, RI and PI were positively correlated with clinical stage, lymph node metastasis, MYBL2 expression level and MTA1 expression level, and negatively correlated with differentiation degree ( P<0.001) . Conclusion:The expression levels of MYBL2 and MTA1 in breast cancer tissue are correlated with the ultrasonic shear wave elastography and blood flow quantitative parameters, which can be used as an important reference index for clinical diagnosis and treatment of breast cancer.
