Effects of vitamin D and ethinyl estradiol and cyproterone tablets on ovarian function and glucose and lipid metabolism in patients with polycystic ovary syndrome
10.3760/cma.j.cn115807-20240726-00248
- VernacularTitle:维生素D与炔雌醇环丙孕酮片对多囊卵巢综合征患者卵巢功能及糖脂代谢的影响
- Author:
Xia ZHANG
1
;
Fei LI
;
Aiqin NIU
Author Information
1. 商丘市第一人民医院妇科，商丘 476100
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Ethinyl estradiol and cyproterone tablets;
Polycystic ovary syndrome;
Ovarian function;
Glucose and lipid metabolism
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):806-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of vitamin D and ethinyl estradiol and cyproterone tablets in the treatment of patients with polycystic ovary syndrome (PCOS) on ovarian function and glucose and lipid metabolism.Methods:147 PCOS patients treated in our hospital from Jan. 2021 to May. 2023 were selected as the research objects. According to the different treatment methods, they were divided into a control group of 75 cases and an observation group of 72 cases. The control group were treated with dynylestradiol and cyproterone. Ketone tablets treatment, the observation group was supplemented with vitamin D on the basis of the control group. Fasting blood-glucose (FPG), total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL cholesterol (LDL-C), fasting serum insulin (FINS) ], as well as improvement in ovarian function (menstrual scarcity, ovulation and pregnancy), clinical efficacy of treatment, and occurrence of adverse effects.Results:After treatment, FPG, FINS, TC, TG, and LDL-C levels in the observation group were significantly lower and HDL-C levels were significantly higher in the observation group than those in the control group ( P<0.05). After treatment, MOD and AFC were significantly higher and ovarian volume was significantly lower in the observation group than those in the control group ( P<0.05). The rate of scanty menstruation was 13.89%, the rate of ovulation was 83.33%, and the rate of pregnancy was 62.50% in the observation group, and 62.50%, 64.00%, and 44.00% in the control group, respectively. Scanty menstruation in the observation group was significantly lower than that in the control group, and the improvement of ovulation and pregnancy was significantly higher than that in the control group ( P<0.05). The total effective rate in the observation group was 95.83.%, and that in the control group was 73.33%, the total efficiency of the observation group was higher than that of the control group ( P<0.05). The incidence of adverse reactions during the treatment period was 6.94% in the observation group and 9.33% in the control group, and there was no significant difference in the incidence of adverse reactions between the two groups ( P>0.05) . Conclusion:The combination of vitamin D and ethinyl estradiol and cyproterone tablets in the treatment of PCOS can more effectively improve ovarian function and glucose and lipid metabolism, increase ovulation rate and pregnancy rate, with definite clinical results and fewer adverse reactions.
