Predictive value of combined IAA, ICA, and GADA tests for pregnancy outcome in patients with gestational diabetes mellitus
10.3760/cma.j.cn115807-20240814-00267
- VernacularTitle:妊娠期糖尿病患者IAA、ICA、GADA联合检测对妊娠结局的预测价值
- Author:
Jie NIU
1
;
Jinhua ZHANG
;
Honglian ZHAO
;
Yilin REN
;
Aihua TONG
Author Information
1. 临沂市中心医院内分泌科，临沂 276400
- Publication Type:Journal Article
- Keywords:
Gestational diabetes mellitus;
Pregnancy outcome;
Insulin autoantibodies;
Islet cell antibodies;
Glutamic acid decarboxylase antibodies
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):801-805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the predictive value of combined insulin autoantibody (IAA), islet cell antibody (ICA), and serum glutamic acid decarboxylase antibody (GADA) testing for pregnancy outcome in patients with gestational diabetes mellitus (GDM) .Methods:One hundred and twenty patients with GDM were retrospectively selected for the study, and were divided into a poor pregnancy outcome group and a normal pregnancy outcome group based on the pregnancy outcome at follow-up to delivery, which were 37 and 83 cases, respectively. The occurrence of adverse pregnancy outcomes in the study population was counted, and univariate and multivariate analyses of adverse pregnancy outcomes in GDM were performed.Results:Adverse pregnancy outcomes were seen in 37 of the 120 study subjects, including 12, 13 and 9 cases of macrosomia, caesarean section and neonatal hypoglycaemia, respectively, and 1 case of premature rupture of the foetal hairs, placenta previa and neonatal asphyxia. The percentage of IAA, ICA, and GADA positivity was higher in the adverse pregnancy outcome group than in the normal pregnancy outcome group ( P<0.05). Multifactorial regression analysis showed that IAA ( OR=3.180, 95% CI 1.394-7.258), ICA ( OR=3.459, 95% CI 1.592-7.517), and GADA ( OR=3.219, 95% CI 1.508-6.872) positivity were independent risk factors for adverse pregnancy outcomes in GDM ( P<0.05). The AUC values for the combined IAA, ICA, and GADA for the detection of adverse pregnancy outcomes in GDM were higher than those for IAA, ICA, and GADA alone ( Z=2.607, 2.600, and 2.527, P<0.05) . Conclusion:Positive IAA, ICA, and GADA are risk factors for adverse pregnancy outcomes in patients with GDM, and combined testing has a higher predictive value.
