Correlation between the methylation of the FOS gene and the occurrence of osteoporosis in patients with gestational diabetes
10.3760/cma.j.cn115807-20240319-00080
- VernacularTitle:FOS基因甲基化与妊娠期糖尿病骨质疏松症的关联性研究
- Author:
Lili ZHANG
1
;
Hua SHU
;
Lanlan ZHANG
;
Shuai ZHANG
;
Tiantian WANG
Author Information
1. 济宁医学院附属医院风湿免疫科，济宁 272000
- Publication Type:Journal Article
- Keywords:
Methylation of the FOS gene;
Gestational diabetes mellitus;
Osteoporosis
- From:
Chinese Journal of Endocrine Surgery
2025;19(1):85-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between the methylation of the FOS gene and the occurrence of osteoporosis (OP) in patients with gestational diabetes mellitus (GDM) .Methods:From Aug. 2017 to Aug. 2022, 120 patients with gestational diabetes mellitus (GDM) were collected in Affiliated Hospital of Jining Medical College as the research subjects. According to the bone density values, the research subjects were divided into the OP group (15 cases) and the non-OP group (105 cases) . The methylation status of the FOS gene was detected in the two groups of patients, and levels of blood calcium (Ca) , phosphorus (P) , β-collagen special sequence ( β-CTX) , procollagen I n-terminal propeptide (PINP) , osteocalcin (OC) , and bone alkaline phosphatase (AKP) were measured to analyze the correlation between FOS gene methylation and osteoporosis (OP) . Results:The frequency of FOS methylation in the OP group patients [66.67% (10/15) ] was significantly higher than that in the non-OP group patients [28.57% (30/105) ] ( χ2=8.57, P=0.003) . Compared to the non-OP group, patients in the OP group showed significant decreases in AKP and OC levels (AKP: 19.05±3.65 vs. 12.98±3.09, t=6.13, P<0.001) (OC: 12.76±1.74 vs. 9.12±1.49, t=7.70, P<0.001) , with no statistically significant differences in Ca, P, β-CTX, or PINP between the two groups ( P>0.05) . Among OP group patients, those who were FOS methylation positive showed significantly lower bone density, AKP, and OC levels compared to FOS methylation negative patients (bone density: 0.38±0.05 vs. 0.31±0.06, t=2.24, P=0.043) (AKP: 16.20±1.68 vs. 11.47±2.34, t=4.00, P=0.001) (OC: 10.27±1.55 vs. 8.58±1.14, t=2.41, P=0.032) . In Logistic multivariate analysis, FOS methylation was found to be a risk factor for osteoporosis in GDM pregnant women ( OR=1.17, 95% CI=0.04-4.26, P=0.027) , while bone density ( OR=0.71, 95% CI=0.42-2.10, P=0.012) , AKP ( OR=0.53, 95% CI=0.24-1.90, P=0.008) , and OC ( OR=0.90, 95% CI=0.17-5.18, P=0.021) were identified as protective factors for GDM patients against osteoporosis. Conclusion:The methylation of the FOS gene is significantly associated with the occurrence of OP in pregnant women with GDM, and it can increase the risk of OP in pregnant women with GDM.
