Diagnostic value of contrast-enhanced ultrasound combined with fine needle aspiration biopsy for TI-RADS 4 type thyroid micro-nodules
10.3760/cma.j.cn231583-20240411-00095
- VernacularTitle:超声造影联合细针穿刺活检对TI-RADS4类甲状腺微小结节的诊断价值
- Author:
Meiyuan LI
1
;
Yan CAI
1
;
Yangming XU
1
;
Shuxian CHEN
1
;
Kanghong WU
1
Author Information
1. 湛江中心人民医院超声医学科，湛江 524000
- Publication Type:Journal Article
- Keywords:
Contrast-enhanced ultrasound;
Fine needle aspiration biopsy;
Thyroid nodules
- From:
Chinese Journal of Endemiology
2025;44(5):410-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the diagnostic value of contrast-enhanced ultrasound (CEUS) combined with fine needle aspiration biopsy (FNA) for thyroid imaging reporting and data system (TI-RADS) 4 type thyroid micro-nodules (TN).Methods:A total of 121 TI-RADS 4 TN patients admitted to Zhanjiang Central People's Hospital from June 2020 to June 2023 were selected as the research subjects. All patients underwent examinations such as CEUS, FNA, and pathology (as the gold standard). The CEUS manifestations of TI-RADS 4 benign and malignant nodules were observed. The diagnostic accuracy, sensitivity, and specificity of CEUS and FNA alone and in combination for TI-RADS 4 type TN benign and malignant nodules were calculated and compared.Results:Among the 121 patients, there were 109 females and 12 males, with an age of (48.27 ± 7.76) years. Pathological diagnosis showed 74 cases of malignancy and 47 cases of benign. CEUS diagnosed 64 cases of malignancy and 57 cases of benign, with a diagnostic accuracy of 86.49% (64/74); the CEUS manifestations of benign and malignant nodules were compared in terms of enhancement mode, enhancement level, uniformity, peripheral ring shape, and post enhancement boundary, and the differences were statistically significant ( P < 0.001). FNA diagnosed 62 cases of malignancy and 59 cases of benign, with a diagnostic accuracy of 83.78% (62/74). CEUS combined with FNA diagnosed 72 cases of malignancy and 49 cases of benign, with a diagnostic accuracy rate of 97.30% (72/74). The accuracy of CEUS combined with FNA in diagnosing malignant nodules was higher than that of CEUS and FNA alone ( P < 0.05). The sensitivity and specificity of CEUS combined with FNA in diagnosing malignant nodules were higher than those of CEUS and FNA alone ( P < 0.05). Conclusion:The combination of CEUS and FNA has good diagnostic value for TI-RADS 4 type TN, which can improve the accuracy and diagnostic efficiency of malignant nodule diagnosis.
