Correlation between serum NRP1 level and postoperative recurrence in patients with adenomyosis
10.3760/cma.j.cn115807-20240703-00228
- VernacularTitle:血清NRP1水平与子宫腺肌症患者术后复发的相关性研究
- Author:
Meiting WANG
1
;
Jinjin DING
;
Jieqiong LIANG
Author Information
1. 临汾市人民医院妇科，临汾 041000
- Publication Type:Journal Article
- Keywords:
Neuropilin 1;
Uterine adenomyosis
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):909-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum Neuropilin 1 (NRP1) level and postoperative recurrence in patients with adenomyosis.Methods:From Mar. 2019 to Mar. 2021, 80 patients with adenomyosis admitted to our hospital were regarded as the test group; 80 healthy women who came to our hospital for physical examination were as the reference group. Patients with adenomyosis were followed up for 24 months after surgery and were separated into a non recurrence group (62 cases) and recurrence group (18 cases) based on whether there was recurrence after surgery. Enzyme-linked immunosorbent assay (ELISA) was applied to detect NRP1 level in the serum of the study subjects. Spearman method was applied to analyze the correlation between serum NRP1 level and visual analogue dysmenorrhea score (VAS) and menstrual blood loss (PBAC) scores in patients with adenomyosis. Multivariate Logistic regression was applied to analyze the influencing factors of postoperative recurrence in patients with adenomyosis. Receiver operating characteristic (ROC) curve was applied to analyze the predictive value of serum NRP1 level for postoperative recurrence in patients with adenomyosis.Results:Compared with the reference group, the serum NRP1 level of patients with adenomyosis in the test group was obviously increased ( P<0.05). Compared with the non recurrence group, the recurrence group showed a obvious increase in serum NRP1 level, uterine volume, dysmenorrhea VAS score, and PBAC score ( P<0.05). Spearman’s method showed a positive correlation between serum NRP1 level and dysmenorrhea VAS score in patients with adenomyosis ( r=0.604, P<0.001) ; the serum NRP1 level in patients with adenomyosis was positively correlated with PBAC score ( r=0.586, P<0.001) ; the serum NRP1 level in patients with adenomyosis was positively correlated with uterine volume ( r=0.527, P<0.001). The results of multivariate logistic regression analysis showed that serum NRP1 level, uterine volume, dysmenorrhea VAS score, and PBAC score were risk factors for postoperative recurrence in patients with adenomyosis ( P<0.05). The ROC curve showed that the AUC of serum NRP1 level in predicting postoperative recurrence in patients with adenomyosis was 0.903, which had certain clinical value. Conclusion:The serum NRP1 level in patients with adenomyosis obviously increases, which is closely related to postoperative recurrence in patients with adenomyosis.
