Influence of Jiegu Qili Tablets Combined with Percutaneous Vertebroplasty on Bone Metabolism Markers and BMP-2 and BMP-7 in Patients with Osteoporotie Vertebral Compression Fractures
10.13241/j.cnki.pmb.2025.19.009
- VernacularTitle:接骨七厘片联合经皮椎体成形术对骨质疏松性胸腰椎压缩骨折患者骨代谢标志物和BMP-2、BMP-7的影响
- Author:
Gang TANG
1
;
Yu-hui SONG
1
;
Yong XIAO
1
Author Information
1. 吉安市永丰县人民医院骨科 江西吉安 331500
- Publication Type:Journal Article
- Keywords:
Jiegu Qili Tablets;
Percutaneous vertebroplasty;
Osteoporotie vertebral compression fractures;
Bone metabolism markers;
Bone morphogenetic protein-2;
Bone morphogenetic protein-7
- From:
Progress in Modern Biomedicine
2025;25(19):3098-3105,3138
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the influence of Jiegu Qili Tablets combined with percutaneous vertebroplasty(PVP)on bone metabolism markers and bone morphogenetic protein-2(BMP-2)and bone morphogenetic protein-7(BMP-7)in patients with osteoporotie vertebral compression fractures(OVCF).Methods:This study was a prospective study,150 patients with OVCF due to qi stagnation and blood stasis syndrome who were admitted to our hospital from April 2022 to April 2024 were divided into control group(received PVP treatment,n=75)and observation group(received Jiegu Qili Tablets on the basis of the control group,n=75)according to the random number table method.Visual analogue scale(VAS),TCM syndrome score and Oswestry dysfunction index(ODI)vertebro-related indicators(anterior compression rate of the injured vertebrae,Cobb's Angle of the injured vertebrae),disappearance time of major symptoms and fracture healing time,bone metabolism markers[bone gla protein(BGP),Beta C-terminal cross-linked telopeptides of type Ⅰ collagen(β-CTX),bone alkaline phosphatase(BALP)]and BMP-2,BMP-71evels before treatment and one month after treatment were compared between the two groups.Results:One month after treatment,the main symptoms,secondary symptoms,total score,VAS,ODI scores,serum β-CTX,BALP levels,anterior compression rate of the injured vertebrae,and Cobb's Angle of the injured vertebrae in the observation group were lower than those in the control group.The disappearance time of the main symptoms and fracture healing time in the observation group were shorter than those in the control group,BGP,BMP-2 and BMP-7 were higher than those in the control group(P＜0.05).Conclusion:Jiegu Qili Tablets combined with PVP in the treatment of patients with OVCF,can effectively promote fracture healing in patients by improving bone metabolism markers and BMP-2 and BMP-7 levels,and is conducive to postoperative recovery of patients.
