The Correlation between MMR and PD-L1 Protein Expression and Clinical Pathological Characteristics in Colorectal Cancer Tissues
10.13241/j.cnki.pmb.2025.19.003
- VernacularTitle:结直肠癌组织中MMR与PD-L1蛋白表达与临床病理特征的相关性
- Author:
Xian-jie MENG
1
;
Li XIAO
;
Hai-jun ZHANG
;
Jian-ming HU
;
Li WEI
Author Information
1. 石河子市人民医院病理科 新疆石河子 832000
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Mismatch repair;
Histological differentiation;
Programmed death ligand 1;
Lymph node metastasis;
Correlation
- From:
Progress in Modern Biomedicine
2025;25(19):3056-3061,3113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore and analyze the correlation between the expression of mismatch repair(MMR)protein and programmed death ligand 1(PD-L1)in colorectal cancer(CRC)tissue and clinical pathological characteristics.Methods:The study period were from July 2021 to December 2024,200 cases of colorectal cancer patients treated in our hospital were selected as the research subjects.Collected all patient lesion tissue samples(lesion group)and adjacent tissue samples(located ≥5 cm from the tumor edge,adjacent group),and used the immunohistochemistry(IHC)method to detect the expression of Mismatch repair(MMR)(MLH1,MSH2,MSH6,and PMS2)protein and PD-L1 protein.Investigated the clinical and pathological characteristics of patients and conducted correlation analysis.Results:The positive rates of dMMR and pMMR protein expression in the lesion group were 39.00％and 70.00％,respectively,while those in the adjacent cancer group were 11.00％and 89.00％,respectively.There were significant difference compared between the lesion group and the adjacent cancer group(P＜0.05).The positive rate of PD-L1 protein expression in the lesion group were 25.00％,while that in the adjacent cancer group were 80.00％.The expression of PD-L1 protein in the lesion group were significantly lower than that in the adjacent cancer group(P＜0.05).There were significant differences in the positive rates of MMR and PD-L1 protein expression among patients with different histological differentiation,clinical stages,and lymph node metastasis(P＜0.05),while there were no significant differences in the positive rates of MMR and PD-L1 protein expression among patients of different genders,ages,and disease sites(P＞0.05).Spearman analysis showed there were correlation between the expression of MMR and PD-L1 proteins in colorectal cancer tissues and clinical pathological features such as histological differentiation,clinical staging,and lymph node metastasis(P＜0.05).Conclusion:Low expression of MMR and PD-L1 proteins are commonly observed in colorectal cancer tissues.The expression of MMR and PD-L1 proteins in colorectal cancer tissues are correlated with clinical pathological features such as histological differentiation,clinical staging,and lymph node metastasis.
