Associations of peripheral blood eosinophils with glycolipid and uric acid metabolism in type 2 diabetes mellitus patients
10.3760/cma.j.cn115822-20241127-00216
- VernacularTitle:2型糖尿病患者外周血嗜酸性粒细胞与糖脂和尿酸代谢的相关性
- Author:
Ruiling SHI
1
;
Shihan WANG
;
Tao YUAN
;
Shuoning SONG
;
Yong FU
;
Weigang ZHAO
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院全科医学科（普通内科），北京 100730
- Publication Type:Journal Article
- Keywords:
Eosinophils;
Glucose and lipid metabolism;
Uric acid;
Type 2 diabetes mellitus
- From:
Chinese Journal of Clinical Nutrition
2025;33(2):90-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the influencing factors of glycemic control among type 2 diabetes mellitus (T2DM) patients, in particular the correlations between peripheral blood eosinophils and metabolic indicators such as glucose, lipids, and uric acid (UA) in these patients.Methods:T2DM patients who were regularly followed up in the Intensive Diabetes Mellitus Clinic of Peking Union Medical College Hospital from January 2016 to September 2024 were prospectively selected as the research subjects. The clinical data of these patients at their first visit and at the 3rd, 6th, 9th, and 12th months of follow-up were collected. The potential correlations of peripheral blood eosinophils with blood glucose control, lipid metabolism, UA metabolism, and inflammation as well as their influencing factors were analyzed.Results:A total of 161 T2DM patients were included. The glycated hemoglobin A1c (HbA1c) compliance rate was significantly higher during the follow-up visits (3, 6, 9, and 12 months) than baseline (all P<0.05) but showed no significant correlation with the count or percentage of peripheral blood eosinophils. Spearman correlation analysis showed that the percentage of peripheral blood eosinophils was negatively correlated with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) ( P=0.049) and high-density lipoprotein cholesterol (HDL-C) ( P=0.002) and positively with serum triglyceride (TG) ( P=0.034) and UA levels ( P<0.001). A further linear regression model analysis of these four variables and the percentage of eosinophils revealed that the percentage of peripheral blood eosinophils was only linearly correlated with serum UA level ( P<0.001). Conclusion:The percentage of peripheral blood eosinophils in T2DM patients is independently correlated with serum UA level, and monitoring serum UA level is important in T2DM management. Early identification and intervention of hyperuricemia can help provide more comprehensive and precise medical interventions for T2DM patients.
