Chest HRCT Findings of Idiopathic Inflammatory Myopathy with Positive and Negative Anti-Ro-52 Antibodies:A Comparative Study
10.3969/j.issn.1005-5185.2025.01.008
- VernacularTitle:抗Ro-52抗体阳性与阴性特发性炎性肌病胸部高分辨率CT表现对照研究
- Author:
Mingxia ZHANG
1
;
Ling LI
;
Lan GAO
;
Ying SUN
;
Lei SUN
;
Meng HUO
;
Chunyan ZHANG
;
Yuhua WANG
;
Rengui WANG
Author Information
1. 首都医科大学附属北京世纪坛医院放射科,北京 100038
- Publication Type:Journal Article
- Keywords:
Dermatomyositis;
Polymyositis;
Antibody;
Lung diseases,interstitial;
Tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging
2025;33(1):48-52,62
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To compare the HRCT findings of lung damage in patients with idiopathic inflammatory myopathies(IIMs)with positive and negative anti-Ro-52 antibody.Materials and Methods Fifty patients with IIMs admitted to Beijing Shijitan Hospital,Capital Medical University from January 2015 to July 2023 were retrospectively analyzed.The patients were divided into anti-Ro-52 antibody negative group(18 cases)and positive group(32 cases),the lung CT findings of the two groups were compared,the distribution of lung lesions and related signs were analyzed.Results The incidence of interstitial lung disease in the anti-Ro-52 antibody-negative group was 11.1%(1 case),which was lower than that in the positive group 75.6%(31 cases)(P=0.001).Among the interstitial lung disease-positive patients,the proportion of lesions in the anti-Ro-52 positive group was more symmetrical(28 cases,87.5%,P=0.022)and peripheral distribution(20 cases,62.5%,P=0.039)than that in the anti-Ro-52 negative group.Non-specific interstitial pneumonia-like lesions were the main lesions in the two groups,including 14 cases(43.8%)in the anti-Ro-52 positive group and 7 cases(38.9%)in the negative group.However,9 cases(28.1%)of the anti-Ro-52 positive group had acute interstitial pneumonia-like lesions and 1 case(5.6%)of the negative group had acute interstitial pneumonia-like lesions.Imaging accompanying signs:anti-Ro-52 positive combination and consolidation(14 cases,43.8%,P=0.009),nodular shadow(17 cases,53.1%,P=0.025),and reverse halo sign(12 cases,37.5%,P=0.021)were more than those in the anti-Ro-52 negative group.Conclusion IIMs patients with positive anti-Ro-52 antibody have a higher incidence of interstitial lung disease.HRCT findings are of great significance for diagnosis and treatment of IIMs.
