The role of eosinophils in regulating glycolipid metabolism and its clinical application prospects
10.3760/cma.j.cn115822-20240312-00046
- VernacularTitle:嗜酸性粒细胞在糖脂代谢调节中的作用及其临床应用展望
- Author:
Ruiling SHI
1
;
Tao YUAN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院全科医学科（普通内科），北京 100730
- Publication Type:Journal Article
- Keywords:
Eosinophil;
Glycolipid metabolism;
Diabetes mellitus;
Insulin resistance;
Diabetes mellitus reversion;
Diabetic complications
- From:
Chinese Journal of Clinical Nutrition
2025;33(1):65-71
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a common metabolic disease with serious complications. As people's lifestyle changes, the incidence of diabetes mellitus has gradually increased, and diabetes mellitus has become a global public health issue. Recent studies have found a correlation between blood sugar and eosinophils. Eosinophils may affect the differentiation direction of bone marrow-derived macrophages by promoting the development of beige fat, controlling local inflammation, regulating cell energy metabolism, and resisting vasoconstriction, thereby improving glucose tolerance and insulin resistance and lowering blood sugar levels. In addition, eosinophils are also associated with diabetic ketoacidosis to some extent. This review summarizes the relationship between glycolipid metabolism and eosinophils from the perspectives of phenomenon, mechanism, and clinical application, and speculates that it may play an important role in monitoring the course of diabetes mellitus and reversing diabetes mellitus.
