Risk score model based on clinical and multimodal ultrasound features for differentiating benign and malignant BI-RADS 4A breast lesions
10.13929/j.issn.1672-8475.2025.01.005
- VernacularTitle:基于临床及多模态超声特征风险评分模型鉴别乳腺BI-RADS 4A类良、恶性病变
- Author:
Qifan LIU
1
;
Shuai CUI
1
;
Wenjing GUO
1
;
Wei LI
1
;
Hailong WANG
1
;
Husha LI
1
;
Jundong YAO
1
;
Zhoulong ZHANG
1
Author Information
1. 河南科技大学第一附属医院超声科,河南 洛阳 471000
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
pathology;
ultrasonography;
breast imaging reporting and data system;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(1):22-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of risk score model based on clinical and multimodal ultrasound features for differentiating benign and malignant breast imaging reporting and data system(BI-RADS)4A lesions in breast.Methods Totally 177 patients with BI-RADS 4A lesions detected by multimodal breast ultrasound were prospectively enrolled,and the patients were divided into training set(n=123)and test set(n=54)at the ratio of 7∶3.Univariate and multivariate logistic regression analyses were used to analyze patients'clinical,gray-scale ultrasound,CDFI and elastography ultrasound parameters of lesions,and the independent risk factors for differentiating benign and malignant BI-RADS 4A lesions in breast were screened,so as a risk score model was constructed.Based on the results of sungical pathology or follow-up,the cut-off value of the model for differentiating benign and malignant BI-RADS 4A lesions in breast was obtained by receiver operating characteristic(ROC)curve,and the patients were divided into high-risk and low-risk subgroups according to the cut-off value,and the efficacy of the model was evaluated.Results Among 177 cases,39 were with benign lesions and 138 were with malignant lesions.Patients'age＞58 years,diameter of lesion＞15.1 mm,lesions with irregular shape,lesions with grade 1 or 2 of blood flow and standard deviation of sound touch elastography of a 2 mm circular area around the lesion(shell)(shell-STESD)＞16.33 kPa were all independent risk factors of malignant BI-RADS 4A lesions in breast.The cut-off value of risk score model for differential diagnosis was 6.5 points,and its sensitivity was 84.69%(83/98)and specificity was 88.00%(22/25)in distinguishing high-risk and low-risk subgroups in training set,while its sensitivity was 77.50%(31/40)and specificity was 71.43%(10/14)in test set.Conclusion Risk score model based on clinical and multimodal ultrasound features could effectively differentiate benign and malignant BI-RADS 4A lesions in breast.
