Research Progress on Artemisinin and Its Derivatives to Improve Female Reproductive Diseases
- VernacularTitle:青蒿素及其衍生物改善雌性生殖疾病的研究进展
- Author:
Jianying CHANG
1
;
Mingyue WEI
;
Jingjing LI
;
Zilong CHEN
;
Yujin MA
;
Huifeng MA
;
Lei ZHANG
;
Tao JIANG
;
Chuanxin LIU
;
Hongwei JIANG
Author Information
- Publication Type:Journal Article
- Keywords: Artemisinin and its derivatives; Female reproductivediseases; Endogenous insults; Exogenous insults; Compromised fertility; Fertility-protective agents
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(11):3386-3399
- CountryChina
- Language:Chinese
- Abstract: The female reproductive system is essential for sustaining reproductive endocrine homeostasis,however,its vulnerability to various endogenous and exogenous insults,including pathological conditions,pharmacological agents,genetic predispositions,and environmental factors,often results in compromised fertility.The existing protective approaches(including surgical interventions,hormonal replacement therapies,and assisted reproductive techniques)are constrained by several limitations,such as adverse therapeutic effects,technical complexities,and their incapacity to reverse ovarian senescence.Artemisinin and its derivatives(ARTs),characterized by their unique endoperoxide bridge configuration,have exhibited outstanding therapeutic performance across multiple domains including malaria treatment,anticancer therapy,inflammation modulation,and parasitic infection control.Emerging research has identified their novel protective capabilities against various reproductive system pathologies.This comprehensive review systematically elucidates the molecular mechanisms underlying artemisinin-based interventions in reproductive pathologies and evaluates their clinical translation prospects,thereby proposing innovative strategies for the development of next-generation fertility-protective agents with enhanced safety and efficacy profiles.
