Advances in Lipidomics Research on Metabolic Associated(Non-alcoholic)Steatohepatitis
- VernacularTitle:脂质组学在代谢相关(非酒精性)脂肪性肝炎中的应用进展
- Author:
Lei XIAO
1
;
Kaiyang LI
;
Mei YANG
;
Qi ZHAO
Author Information
- Publication Type:Journal Article
- Keywords: Lipidomics; Lipidmetabolism disorder; Metabolic associated steatohepatitis; Non-alcoholic fatty liver disease
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(11):3362-3372
- CountryChina
- Language:Chinese
- Abstract: Metabolic associated(non-alcoholic)steatohepatitis(MASH/NASH)is a progressive form of metabolic associated(non-alcoholic)fatty liver disease(MAFLD/NAFLD),characterized by hepatic fat accumulation,inflammation,with or without fibrosis.It can further progress to liver cirrhosis or hepatocellular carcinoma,and it is a common and frequently-occurring liver disease.In recent years,due to its unique advantages in analyzing lipid metabolism disorders,lipidomics has become an important tool in the research of MASH/NASH.This article reviews the role of lipidomics in elucidating the pathological mechanisms of MASH/NASH,discovering biomarkers,and exploring therapeutic targets,aiming to provide a theoretical basis for basic research and new drug development for MASH/NASH.
