Current situation analysis and quality evaluation of guidelines and consensus in ovarian stimulation for in vitro fertilization
10.3760/cma.j.cn101441-20250305-00105
- VernacularTitle:体外受精促排卵领域指南与共识的现况分析与质量评价
- Author:
Yuan GAO
1
;
Zaiwei SONG
;
Dan JIANG
;
Rui YANG
;
Yuwen HUANG
;
Rong LI
;
Rongsheng ZHAO
Author Information
1. 北京大学第三医院药学部 北京大学医学部药物评价中心，北京 100191
- Publication Type:Journal Article
- Keywords:
In vitro fertilization;
Ovarian stimulation;
Clinical guidelines;
Expert consensus;
Systematic review
- From:
Chinese Journal of Reproduction and Contraception
2025;45(8):818-825
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the current status and methodological quality of guideline and consensus in ovarian stimulation for in vitro fertilization (IVF), and to provide reference for the development of future guidelines and research. Methods:A systematic search was conducted in databases including PubMed, Embase, CNKI, Wanfang, Sinomed and relevant guideline websites from inceptions to October 2024. Data were extracted from the literature that met the inclusion criteria, and methodological quality was assessed using the Appraisal of Guidelines for Research and Evaluation Ⅱ (AGREE Ⅱ) tool. Descriptive analysis was performed with results presented in visual data charts.Results:A total of 23 studies were included, with 8 guidelines and 15 consensus. Totally 21 (91.3%) studies focused on the selection of ovarian stimulation protocols, with the majority concentrating on protocols for patients undergoing IVF treatment for the first cycle, and 12 (52.2%) studies focused on the selection of gonadotropin starting dosage. In terms of methodology, the average standardized scores in the 6 assessment domains of the AGREE Ⅱ tool were as follows: scope and purpose (85.1%), stakeholder involvement (66.6%), rigour of development (36.5%), clarity of presentation (70.1%), applicability (36.4%), and editorial independence (46.2%).Conclusion:Current recommendations in ovarian stimulation for IVF exhibit inconsistencies, and the methodological quality varies, which partially hinders the translation of evidence into clinical practice. Future research should further focus on the selection of ovarian stimulation protocols and gonadotropin starting dosage, promoting the update and refinement of guidelines and consensus to guide the precise treatment of ovarian stimulation.
