Differential Diagnosis of Amide Proton Transfer Imaging Combined with Diffusion Weighted Imaging in Prostate Cancer and Benign Prostatic Hyperplasia
10.3969/j.issn.1005-5185.2025.01.013
- VernacularTitle:酰胺质子转移成像联合扩散加权成像对前列腺癌及前列腺增生的鉴别价值
- Author:
Huijia YIN
1
;
Xuekun LI
1
;
Ruifang YAN
1
;
Dongming HAN
1
Author Information
1. 新乡医学院第一附属医院磁共振科,河南 卫辉 453100
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Amide proton transfer imaging;
Diffusion weighted imaging;
Prostatic neoplasms;
Prostatic hyperplasia;
Diagnosis,differential
- From:
Chinese Journal of Medical Imaging
2025;33(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of magnetic resonance amide proton transfer(APT)imaging combined with diffusion weighted imaging(DWI)in the differential diagnosis of prostate cancer and benign prostatic hyperplasia.Materials and Methods A retrospective analysis was made on 52 patients with prostate cancer and 60 patients with benign prostatic hyperplasia in the First Affiliated Hospital of Xinxiang Medical University from February 2020 to August 2021.The APT parameter values magnetization transfer ratio asymmetry(MTRasym)and DWI parameter values apparent diffusion coefficient(ADC)of the two groups were measured,respectively.The parameter differences between the two groups were compared and analyzed,the significant parameters and the efficacy of their joint diagnosis were evaluated.Then compared the performance of each parameter and joint diagnosis,and analyze the correlation between the two parameters.Results The MTRasym in the prostate cancer group[(3.70±0.94)%]was significantly higher than that in the prostate hyperplasia group[(2.35±0.60)%](t=8.89,P＜0.05);ADC value in prostate cancer group[(0.93±0.15)×10-3 mm2/s]was significantly lower than that in the prostate hyperplasia group[(1.32±0.22)×10-3 mm2/s](t=-11.01,P＜0.05).The areas under the curve for identifying prostate cancer and benign prostatic hyperplasia using MTRasym value,ADC value and their combination were 0.886,0.914 and 0.966,respectively.There was no statistically significant difference in the diagnostic efficacy between the MTRasym value and the ADC value(P＞0.05),and the combined diagnostic efficacy of the two was superior to the individual diagnostic efficacy of the MTRasym value and ADC value(Z=3.125,2.776,P＜0.05).The MTRasym was negatively correlated with the ADC value(r=-0.469,P＜0.001).Conclusion APT and DWI have high efficacy in distinguishing between prostate cancer and benign prostatic hyperplasia.The combination of the two sequences has higher diagnostic efficacy.
