Correlation analysis of serum VEGF, vWF and coagulation indexes with prognosis of thyroid cancer
10.3760/cma.j.cn115807-20240428-00142
- VernacularTitle:血清VEGF、vWF及凝血指标与甲状腺癌预后的相关性分析
- Author:
Wei DING
1
;
Yongmin MIAO
;
Wei WANG
;
Meiya LIU
Author Information
1. 山西省肿瘤医院 中国医学科学院肿瘤医院山西医院 山西医科大学附属肿瘤医院头颈外科，太原 030013
- Publication Type:Journal Article
- Keywords:
Thyroid cancer;
Vascular endothelial growth factor;
Coagulation index;
Von Willebrand factor;
Thyroid benign nodule
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):835-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum vascular endothelial growth factor (VEGF), von Willebrand factor (vWF) and coagulation index and prognosis of differentiated thyroid cancer (TC) .Methods:136 TC patients admitted in Department of Head and Neck Surgery Shanxi Cancer Hospital from Jan. 2021 to Dec. 2022 were selected as TC group, and 80 patients with confirmed thyroid benign nodule during the same period were selected as control group. VEGF, vWF and coagulation indexes were compared between the two groups. The tumor free survival was calculated by Kaplan-Meier method.Results:Compared with the control group, the levels of VEGF, vWF, TT, Fbg in TC group were higher, and the levels of PT, APTT were lower ( P < 0.001). Compared with patients < 55 years old, the levels of VEGF, vWF, TT and Fbg were higher in patients ≥55 years old, and the levels of PT and APTT were lower ( P < 0.001). Compared with papillary carcinoma, the levels of VEGF, vWF, TT and Fbg were higher in follicular carcinoma patients, and the levels of PT and APTT were lower ( P < 0.001). The levels of VEGF, vWF, TT and Fbg were higher and the levels of PT and APTT were lower in patients with TNM stage III to IV than in patients with TNM stage I to II ( P < 0.001). Compared with patients without lymph node metastasis, VEGF, vWF, TT, Fbg levels were higher in patients with lymph node metastasis, and PT, APTT levels were lower ( P < 0.001). Compared with patients with tumor size < 2 cm, VEGF and vWF levels were higher in patients with tumor size ≥ 2 cm ( P < 0.001). Survival curve analysis showed that the tumor free survival of high VEGF, high vWF, high TT and high Fbg groups was shorter than that of low VEGF, low vWF, low TT and low Fbg groups (Log-rank=9.149, 8.856, 4.683, 5.867, P < 0.001) . Conclusion:VEGF, vWF and coagulation indexes in TC patients were correlated with clinicopathological features, and were helpful to predict postoperative tumor-free survival.
