Progress in antioxidant effect of exercise for alleviating skeletal muscle dysfunction in chronic obstructive pulmonary disease
10.3969/j.issn.1000-4718.2025.01.023
- VernacularTitle:运动的抗氧化作用缓解慢性阻塞性肺疾病骨骼肌功能障碍的研究进展
- Author:
Chen YANG
1
;
Peijun LI
;
Yingqi WANG
;
Lihua HAN
;
Qinglan HE
;
Xiaodan LIU
;
Weibing WU
Author Information
1. 上海体育大学运动健康学院,上海 200438
- Publication Type:Journal Article
- Keywords:
exercise;
chronic obstructive pulmonary disease;
oxidative stress;
skeletal muscle dysfunction
- From:
Chinese Journal of Pathophysiology
2025;41(1):195-201
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle dysfunction is a common extra-pulmonary complication in patients with chronic ob-structive pulmonary disease(COPD),significantly impacting exercise capacity and quality of life,leading to a poorer prognosis and increased mortality.Oxidative stress closely associates with the development and progression of skeletal muscle dysfunction in COPD.Exercise,a core component of pulmonary rehabilitation,stands as the primary non-pharma-cological treatment for skeletal muscle dysfunction in COPD patients and exerts a positive modulating effect on oxidative stress.This paper reviews the effects of oxidative stress on skeletal muscle dysfunction in COPD and discusses the mecha-nisms by which exercise improves skeletal muscle dysfunction in COPD from an anti-oxidative stress perspective.It has been found that oxidative stress affects the structure and function of muscles in COPD patients by upregulating the protein hydrolysis system,disrupting mitochondrial function,and impairing calcium homeostasis.Mechanisms by which exercise modulates oxidative stress to improve skeletal muscle dysfunction include the activation of antioxidant genes such as silent mating type information regulation 2 homolog 1 and nuclear factor erythroid 2 related factor to enhance the body's antioxi-dant capacity,inhibiting muscle atrophy.Exercise also regulates mitochondrial reactive oxygen species metabolism,im-proving mitochondrial function,and reduces oxidase activity to protect sarcoplasmic reticulum calcium regulation.In con-clusion,the regulation of skeletal muscle oxidative stress by exercise is a crucial target for improving skeletal muscle dys-function in COPD.
