Relationship between Dynamic Changes of NLR,PLR,and SII and Short-term Efficacy and Long-term Prognosis of Patients with Ad-vanced Non-small Cell Lung Cancer
10.11969/j.issn.1673-548X.2025.10.018
- VernacularTitle:NLR、PLR和SII动态变化与晚期非小细胞肺癌短期疗效和远期预后的关系
- Author:
Wanling ZHU
1
;
Lijie MA
1
;
Hao CHEN
1
Author Information
1. 221000 徐州医科大学附属医院呼吸与危重症医学科
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Short-term efficacy;
Neutrophil-to-lymphocyte ratio;
Platelet-to-lymphocyte ratio;
Systemic immune-inflammation index
- From:
Journal of Medical Research
2025;54(10):99-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammatory index(SII)with short-term outcome and long-term prognosis in patients with advanced non-small cell lung cancer(NSCLC).Methods A retrospective study was conducted.A total of 215NSCLC patients who received a complete 4-cycle chemotherapy combined with immunotherapy or chemotherapy alone in the Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Xuzhou Medical University from January 2021 to January 2023 were selected as the research subjects.The patients were divided into remission group(n=97)and non-remission group(n=118)based on the efficacy of the treatments,and the differences in NLR,PLR,SII,and decline rate of each index were compared between the two groups.NLR,PLR,SII and decline rate before and after treatment were grouped by the best cut-off value or median,and the differences in progression-free survival and overall survival were analyzed by each index group.Results NLR and PLR in the remission group before each cycle of treatment were signifi-cantly lower than those in the non-remission group,and SII in the remission group before cycles 2nd,3rd,and 4th of treatment were sig-nificantly lower than those in the non-remission group(P＜0.05);From initial treatment to before the fourth treatment cycle,NLR and SII decline rates in the remission group were significantly higher than those in the non-remission group(P＜0.05);the tumor stage,NLR before cycle 4th of treatment were independent influencing factors of short-term efficacy in patients with advanced NSCLC(P＜0.05);patients with low NLR,PLR,SII and higher rates of decline in NLR and SII before cycle 4th treatment had longer progression-free survival and overall survival(P＜0.05).Conclusion Tumor stage and post-treatment NLR are significantly correlated with the short-term outcomes of patients with advanced NSCLC,and high post-treatment NLR often suggests a poorer response to treatment.The prognosis of advanced NSCLC patients with higher NLR decline rate and higher SII decline rate after treatment is better.
