Correlation between AIP and SIRI with Contrast-induced Acute Kidney Injury after PCI in Hypertensive Patients Complicated with Acute STEMI
10.11969/j.issn.1673-548X.2025.10.021
- VernacularTitle:AIP及SIRI与高血压合并急性STEMI患者PCI术后对比剂急性肾损伤的相关性
- Author:
Jiahui DING
1
;
Jingkun JIN
;
Xishen ZHANG
Author Information
1. 221002 徐州医科大学研究生院
- Publication Type:Journal Article
- Keywords:
Systemic inflammatory response index;
Atherogenic Index of plasma;
Contrast-induced acute kidney injury;
Hyper-tension;
ST-segment elevation myocardial infarction
- From:
Journal of Medical Research
2025;54(10):117-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of the atherogenic index of plasma(AIP)and systemic inflammatory re-sponse index(SIRI)for contrast-induced acute kidney injury(CI-AKI)in patients with hypertension complicated by acute ST-seg-ment elevation myocardial infarction(STEMI)undergoing emergency percutaneous coronary intervention(PCI).Methods A total of 964hypertensive patients with acute STEMI who underwent PCI treatment at the Affiliated Hospital of Xuzhou Medical University from Jan-uary 2021 to April 2025 were retrospectively enrolled.Using a randomized grouping method,the sample was divided into the training group(n=771)and the validation group(n=193)in a ratio of 8∶2.According to the diagnostic criteria for CI-AKI,the training group was further divided into the CI-AKI group(n=151)and the non-CI-AKI group(n=620),with baseline characteristics compared between the two groups.Multivariate Logistic regression models were constructed to identify independent predictors of postoperative CI-AKI,followed by receiver operating characteristic(ROC)curve analysis to evaluate the predictive efficacy of AIP,SIRI,and their combined detection for CI-AKI occurrence after PCI treatment.Results Left ventricular ejection fraction(LVEF),urea metabolism level,high-density lipoprotein cholesterol(HDL-C),diuretics,SIRI,and AIP showed significant correlations with the occurrence of CI-AKI in hypertensive patients with acute STEMI after PCI(P＜0.05).Multivariate Logistic regression analysis revealed that SIRI(OR=1.148,95％CI:1.060-1.244)and AIP(OR=5.946,95％CI:3.250-10.879)were independent risk factors for CI-AKI.The results of ROC curve analysis demonstrated that the combined detection of SIRI and AIP yielded an area under the curve of 0.805(95％CI:0.774-0.835),with the sensitivity of 70.8％and the specificity of 75.0％,which was significantly better than that of indi-vidual indicators(P＜0.001).The results of restricted cubic spline(RCS)indicated that when SIRI ≥ 2.773 or AIP ≥2.089,the risk of CI-AKI increased with rising levels of SIRI and AIP.Conclusion AIP and SIRI are independent risk factors for CI-AKI in hyperten-sive patients with acute STEMI after PCI,and their combined detection can improve the predictive efficacy of CI-AKI in hypertensive pa-tients with acute STEMI following PCI.
