Gender Differences in the Impact of CONUT Score on Diabetic Retinopathy
10.11969/j.issn.1673-548X.2025.10.020
- VernacularTitle:CONUT评分对糖尿病视网膜病变影响的性别差异
- Author:
Yunan HAN
1
;
Lin LI
;
Jinli WANG
Author Information
1. 434000 荆州,长江大学附属第一医院内分泌科;434022 荆州,长江大学医学部
- Publication Type:Journal Article
- Keywords:
Type 2diabetes;
Diabetic retinopathy;
CONUT score;
Gender differences;
Nutritional assessment
- From:
Journal of Medical Research
2025;54(10):110-116,127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the controlling nutritional status(CONUT)score and diabetic retinopathy(DR),and analyze gender differences in this relationship among type 2 diabetes mellitus(T2DM)patients,assessing the clinical appli-cation value of the CONUT score as a tool for evaluating nutritional status in DR.Methods A retrospective analysis was conducted on the clinical data of 1526 patients with T2DM admitted to the First Affiliated Hospital of Yangtze University from January 2022 to September 2024.The patients were categorized into the DR group(n=587)and the non-DR group(n=939)based on the presence of DR.Clini-cal data such as gender,age,educational level,and laboratory parameters were collected,and CONUT scores were calculated.Multivari-ate Logistic regression model and restricted cubic splines(RCS)were employed to assess the relationship between CONUT scores and DR,with stratified and subgroup analyses performed based on gender.Results A significant positive association was found between CONUT scores and the risk of DR.After adjusting for all covariates,higher CONUT scores were significantly associated with an increased risk of DR in male patients(OR=1.215,95％CI:1.030-1.438).The RCS results indicated a linear positive association between CONUT scores and the risk of DR in the general population(Pnonlinear=0.247)and males(Pnonlinear=0.466).Subgroup analysis revealed that the effect of CONUT scores on the risk of DR risk was more pronounced in male patients who were under 60 years of age,had a high school ed-ucation,did not have cardiovascular disease,had a body mass index below 25kg/m2,and were not using hypoglycemic agents.Conclusion The CONUT score effectively assesses the risk of DR in male T2DM patients,demonstrating its application value in clinical practice.
