Prognostic Value of Cerebrospinal Fluid IL-6 and IL-10 for the Prognosis of Primary Intraocular Lymphoma
10.11969/j.issn.1673-548X.2025.10.019
- VernacularTitle:脑脊液IL-6和IL-10对原发性眼内淋巴瘤预后的预测价值
- Author:
Wenjie SUN
1
;
Wei ZHANG
1
Author Information
1. 100005 中国医学科学院/北京协和医学院北京协和医院血液内科
- Publication Type:Journal Article
- Keywords:
Cerebrospinal fluid;
IL-6;
IL-10;
Primary intraocular lymphoma;
Prognosis;
Predictive value
- From:
Journal of Medical Research
2025;54(10):105-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of cerebrospinal fluid interleukin-6(IL-6)and interleukin-10(IL-10)in the prognosis of patients with primary intraocular lymphoma(PIOL).Methods A retrospective study was conducted,60 PIOL pa-tients admitted to Peking Union Medical College,Chinese Academy of Medical Sciences,Peking Union Medical College Hospital from Jan-uary 2018 to December 2022 were selected.Follow-up assessments were conducted for 2 years after discharge to evaluate the prognosis and calculate the incidence of adverse outcomes.Patients with adverse outcomes were classified as the poor prognosis group,while those without adverse outcomes were classified as the good prognosis group.Clinical data at admission were compared between the two groups.Multivariate Logistic regression analysis was used to assess the impact of cerebrospinal fluid IL-6 and IL-10 on prognosis.Receiver op-erating characteristic(ROC)curve were plotted to evaluate the predictive value of cerebrospinal fluid IL-6 and IL-10 for prognosis.Results After 2 years follow-up of 60 patients,22 patients developed adverse outcomes,with an incidence rate of 36.67％.The poor prognosis group included 22 patients,while the good prognosis group included 38 patients.There were statistically significant difference in cerebrospinal fluid IL-6 and IL-10 between the two groups(P＜0.05).The results of multivariate Logistic regression analysis indicated that cerebrospinal fluid IL-6 and IL-10 were risk factors for adverse outcomes.The area under the curve(AUC),sensitivity,and spe-cificity of the combined detection of IL-6 and IL-10 in cerebrospinal fluid for predicting prognosis were 0.879,85.53％and 91.46％,respectively,which were higher than those of single detections of IL-6 or IL-10 in cerebrospinal fluid.Conclusion The combined de-tection of IL-6 and IL-10 in cerebrospinal fluid has a certain predictive value for the prognosis of PIOL patients,with high levels of IL-6 and IL-10 indicating a poor prognosis.
